{"doi":"10.7150/ntno.55165","title":"Tracking adoptive T cell immunotherapy using magnetic particle imaging","abstract":"Adoptive cellular therapy (ACT) is a potent strategy to boost the immune response against cancer. ACT is effective against blood cancers but faces challenges in treating solid tumors. A critical step for the success of ACT immunotherapy is to achieve efficient trafficking and persistence of T cells to solid tumors. Non-invasive tracking of the accumulation of adoptively transferred T cells to tumors would greatly accelerate development of more effective ACT strategies. We demonstrate the use of magnetic particle imaging (MPI) to non-invasively track ACT T cells in vivo in a mouse model of brain cancer. Magnetic labeling did not impair primary tumor-specific T cells in vitro, and MPI allowed the detection of labeled T cells in the brain after intravenous or intracerebroventricular administration. These results support the use of MPI to track adoptively transferred T cells and accelerate the development of ACT treatments for brain tumors and other cancers.","journal":"Nanotheranostics","year":2021,"id":149458,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":106,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":445693,"name":"Lan Hoang-Minh","orcid":"0000-0002-5092-5891","position":1,"is_corresponding":false},{"id":556067,"name":"Andreina Chiu‐Lam","orcid":"0000-0002-4264-8302","position":2,"is_corresponding":false},{"id":556068,"name":"Nicole S. Sarna","orcid":"0000-0002-5643-5850","position":3,"is_corresponding":false},{"id":556069,"name":"Leyda Marrero‐Morales","orcid":"0000-0001-6220-1391","position":4,"is_corresponding":false},{"id":281442,"name":"Duane A. Mitchell","orcid":"0000-0001-6049-213X","position":5,"is_corresponding":false},{"id":247387,"name":"Carlos Rinaldi","orcid":"0000-0001-8886-5612","position":6,"is_corresponding":false},{"id":312037,"name":"Angelie Rivera‐Rodriguez","orcid":"0000-0003-2630-6342","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T23:42:56.251607Z","pmid":"33972919","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}