{"doi":"10.7150/ijms.61552","title":"Alendronate-induced Perturbation of the Bone Proteome and Microenvironmental Pathophysiology","abstract":"Objectives: Bisphosphonates (BPs) are powerful inhibitors of osteoclastogenesis and are used to prevent osteoporotic bone loss and reduce the risk of osteoporotic fracture in patients suffering from postmenopausal osteoporosis. Patients with breast cancer or gynecological malignancies being treated with BPs or those receiving bone-targeted therapy for metastatic prostate cancer are at increased risk of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Although BPs markedly ameliorate osteoporosis, their adverse effects largely limit the clinical application of these drugs. This study focused on providing a deeper understanding of one of the most popular BPs, the alendronate (ALN)-induced perturbation of the bone proteome and microenvironmental pathophysiology. Methods: To understand the molecular mechanisms underlying ALN-induced side-effects, an unbiased and global proteomics approach combined with big data bioinformatics was applied. This was followed by biochemical and functional analyses to determine the clinicopathological mechanisms affected by ALN.","journal":"International Journal of Medical Sciences","year":2021,"id":192174,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":417927,"name":"Austin Yeon","orcid":"0000-0001-5212-234X","position":1,"is_corresponding":false},{"id":419682,"name":"Sarah J. Parker","orcid":"0000-0001-8911-3615","position":2,"is_corresponding":false},{"id":417926,"name":"Muhammad Shahid","orcid":"0000-0002-1317-1621","position":3,"is_corresponding":false},{"id":759215,"name":"Aissatou Thiombane","orcid":null,"position":4,"is_corresponding":false},{"id":758708,"name":"Eunho Cho","orcid":"0000-0002-3409-2535","position":5,"is_corresponding":false},{"id":241817,"name":"Sungyong You","orcid":"0000-0003-3513-1783","position":6,"is_corresponding":false},{"id":462437,"name":"Hany A. Emam","orcid":null,"position":7,"is_corresponding":false},{"id":382604,"name":"Do‐Gyoon Kim","orcid":"0000-0001-7673-1254","position":8,"is_corresponding":false},{"id":758709,"name":"Minjung Kim","orcid":"0000-0002-5682-6640","position":9,"is_corresponding":false},{"id":326160,"name":"Jayoung Kim","orcid":"0000-0002-3683-4627","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T23:49:39.281850Z","pmid":"34400895","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}