{"doi":"10.7150/ijbs.83586","title":"Role Of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer","abstract":"Although recent advances in cancer treatment significantly improved the prognosis of patients, drug resistance remains a major challenge. Targeting programmed cell death is a major approach of antitumor drug development. Deregulation of programmed cell death (PCD) contributes to resistance to a variety of cancer therapeutics. Yes-associated protein (YAP) and its paralog TAZ, the main downstream effectors of the Hippo pathway, are aberrantly activated in a variety of human malignancies. The Hippo-YAP pathway, which was originally identified in Drosophila, is well conserved in humans and plays a defining role in regulation of cell fate, tissue growth and regeneration. Activation of YAP signaling has emerged as a key mechanism involved in promoting cancer cell proliferation, metastasis, and drug resistance. Understanding the role of YAP/TAZ signaling network in PCD and drug resistance could facilitate the development of effective strategies for cancer therapeutics.","journal":"International Journal of Biological Sciences","year":2023,"id":322860,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1037059,"name":"Adrian Lim","orcid":"0000-0002-4638-9395","position":1,"is_corresponding":false},{"id":998228,"name":"Mouad Edderkaoui","orcid":"0000-0002-2549-8242","position":2,"is_corresponding":false},{"id":276997,"name":"Arsen Osipov","orcid":"0000-0002-9000-7040","position":3,"is_corresponding":false},{"id":580410,"name":"Heshui Wu","orcid":"0000-0002-2268-7275","position":4,"is_corresponding":false},{"id":1037060,"name":"Qiang Wang","orcid":"0000-0001-9409-0251","position":5,"is_corresponding":false},{"id":227742,"name":"Stephen J. Pandol","orcid":"0000-0003-0818-6017","position":6,"is_corresponding":false},{"id":262530,"name":"Wei Zhou","orcid":"0000-0001-7719-0859","position":0,"is_corresponding":true}],"reference_count":214,"raw_metadata":null,"created_at":"2026-07-19T01:07:47.432636Z","pmid":"38164167","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}