{"doi":"10.7150/ijbs.70013","title":"Suppressing MDSC Infiltration in Tumor Microenvironment Serves as an Option for Treating Ovarian Cancer Metastasis","abstract":null,"journal":"International Journal of Biological Sciences","year":2022,"id":651610,"datarank":0.5775221402565088,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":0.0,"self_endowment_contribution":0.5775221402565088,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":345059,"name":"Qian Zhang","orcid":"0009-0001-6172-4411","position":1,"is_corresponding":false},{"id":1699471,"name":"Mandi Wu","orcid":null,"position":2,"is_corresponding":false},{"id":281200,"name":"Peidong Zhang","orcid":"0000-0003-4847-2296","position":3,"is_corresponding":false},{"id":1013934,"name":"Liang Huang","orcid":"0009-0001-4185-9677","position":4,"is_corresponding":false},{"id":178162,"name":"Xiaolin Ai","orcid":"0000-0003-0014-1455","position":5,"is_corresponding":false},{"id":178163,"name":"Zhengnan Yang","orcid":"0000-0003-1076-3530","position":6,"is_corresponding":false},{"id":481916,"name":"Qiuhong Shen","orcid":null,"position":7,"is_corresponding":false},{"id":695488,"name":"Yiran Wang","orcid":"0009-0007-3244-3534","position":8,"is_corresponding":false},{"id":332074,"name":"Ping Wang","orcid":"0000-0003-0069-5458","position":9,"is_corresponding":false},{"id":178194,"name":"Shengtao Zhou","orcid":"0000-0001-8322-5536","position":10,"is_corresponding":false},{"id":1699472,"name":"Ming-Liang He","orcid":null,"position":11,"is_corresponding":false},{"id":94006,"name":"Yichen Li","orcid":"0000-0002-9471-9846","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Suppressing MDSC Infiltration in Tumor Microenvironment Serves as an Option for Treating Ovarian Cancer Metastasis","abstract":"It is still a big puzzle how ovarian cancer cells and the tumor microenvironment (TME) attract lymphocytes infiltration for facilitating metastasis, a leading cause of death from gynecological malignancies. Using genome-wide LncRNA microarray assay, here we report that a LncRNA associated with ovarian cancer metastasis (LncOVM) is highly correlated with poor prognosis and survival. LncOVM interacts with and stabilizes PPIP5K2 by suppressing ubiquitinated degradation to promote complement C5 secretion from ovarian cancer cells. The TME-enriched complement C5 attracts myeloid-derived suppressor cells (MDSCs) infiltration in TME to facilitate metastasis. Knockdown of LncOVM or PPIP5K2 inhibits tumor progression in xenograft models. Application of C5aR antibody or inhibitor (CCX168) inhibits MDSC recruitment and restores the suppression of tumorigenesis and metastasis <i>in vivo</i>. Our study reveals that suppression of ovarian cancer metastasis can be achieved by targeting MDSC infiltration in TME through disrupting LncOVM-PPIP5K2-complement axis, providing an option for treating ovarian cancer patients.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35813475","pmcid":"PMC9254473","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://www.ijbs.com/v18p3697.pdf","host_type":"publisher"},{"url":"https://www.ijbs.com/v18p3697.htm","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9254473","host_type":"repository"},{"url":"https://hdl.handle.net/2031/41f07e81-d26f-4d34-911b-bc299954458c","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9254473","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9254473?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Humans","Ovarian Neoplasms","Phosphotransferases (Phosphate Group Acceptor)","Complement C5","Female","Tumor Microenvironment","RNA, Long Noncoding","Myeloid-Derived Suppressor Cells"],"keywords":["Ovarian cancer","Golgi complex","Mdsc","Lncrna","Complement C5","Ppip5k2"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"},{"name":"gen"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T10:08:47.317213Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}