{"doi":"10.7150/ijbs.5.201","title":"Is sodium current present in human sinoatrial node cells?","abstract":null,"journal":"International Journal of Biological Sciences","year":2009,"id":637110,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1349754,"name":"Ronald Wilders","orcid":"0000-0002-1340-0869","position":1,"is_corresponding":false},{"id":1654062,"name":"Marcel M.G.J. van Borren","orcid":null,"position":2,"is_corresponding":false},{"id":1654063,"name":"Hanno L. Tan","orcid":null,"position":3,"is_corresponding":false},{"id":334986,"name":"Arie O. Verkerk","orcid":"0000-0003-2140-834X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Is sodium current present in human sinoatrial node cells?","abstract":"Pacemaker activity of the sinoatrial node has been studied extensively in various animal species, but is virtually unexplored in man. As such, it is unknown whether the fast sodium current (I(Na)) plays a role in the pacemaker activity of the human sinoatrial node. Recently, we had the unique opportunity to perform patch-clamp experiments on single pacemaker cells isolated from a human sinoatrial node. In 2 out of the 3 cells measured, we observed large inward currents with characteristics of I(Na). Although we were unable to analyze the current in detail, our findings provide strong evidence that I(Na) is present in human sinoatrial node pacemaker cells, and that this I(Na) is functionally available at potentials negative to -60 mV.","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19240810","pmcid":"PMC2646265","openalex_id":"https://openalex.org/W1977222851","authors":[],"funders":[],"total_grants":0,"fwci":2.8737,"citation_percentile":0.91170505,"influential_citations":0,"citation_trend":[{"year":2013,"count":5},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2017,"count":4},{"year":2018,"count":6},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://www.ijbs.com/v05p0201.pdf","host_type":"journal"},{"url":"https://www.ijbs.com/v05p0201.pdf","host_type":"publisher"},{"url":"http://www.ijbs.com/v05p0201.htm","host_type":"publisher"},{"url":"https://doi.org/10.7150/ijbs.5.201","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19240810","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/en/publications/2244054f-e342-4eed-854b-cef6cdb016ae","host_type":"repository"},{"url":"https://pure.amc.nl/en/publications/is-sodium-current-present-in-human-sinoatrial-node-cells(98eb966a-8ea1-45d5-add1-ae78031a0b45).html","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2646265","host_type":"repository"},{"url":"https://dare.uva.nl/personal/pure/en/publications/is-sodium-current-present-in-human-sinoatrial-node-cells(f258777f-6f12-4f5c-a34e-861b5a635d9c).html","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC2646265","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC2646265?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cardiac electrophysiology and arrhythmias","ECG Monitoring and Analysis","Cardiac pacing and defibrillation studies"],"mesh_terms":["Biological Clocks","Humans","Membrane Potentials","Sinoatrial Node","Sodium","Patch-Clamp Techniques"],"keywords":["Sinoatrial node","Pacemaker potential","Node (physics)","Internal medicine","Cardiac pacemaker","Patch clamp","Cardiology","Chemistry","Biophysics","Electrophysiology","Biology","Medicine","Heart rate","Physics","Blood pressure","Ion channels","Sodium channels","Action potentials","Humans"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T18:19:55.940355Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}