{"doi":"10.7124/bc.000a8c","title":"Pharmacological blockade of neuraminidase activity does not affect paired-pulse plasticity in hippocampal CA3-to-CA1 network","abstract":"Polysialic acids (PSA) of the outer cell membrane are widely distributed in the neuronal tissue.Their linkages to the glycolipids and glycoproteins are essential for synaptic plasticity.Neuraminidase (NEU) is the main enzyme, which controls PSA population by removing sialic acids from sialoglycoconjugates. Aim.In the present study, we investigated the role of NEU inhibition in hippocampal short-term memory processing.We previously showed that NEU blockage results in a significant decrease in long-term potentiation (LTP) and an increase in short-term depression of hippocampal CA3-to-CA1 network in the stratum radiatum.Methods.Using specific blocker N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid (NADNA), we examined the effect of downregulation of NEU activity on paired-pulse plasticity at Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampus.Results.The present study demonstrates that suppression of endogenous NEU causes an increase in the excitatory postsynaptic potentials without alterations in paired-pulse ratio.Conclusions.Inhibition of NEU activity did not affect paired-pulse plasticity, which reflects changes in the release probability of presynaptic site.We hypothesized that effect of NADNA on basal transmission and LTP is due to the involvement of postsynaptic mechanisms.","journal":"Biopolymers and Cell","year":2023,"id":409013,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":364385,"name":"Elena Isaeva","orcid":"0000-0002-0587-6322","position":1,"is_corresponding":false},{"id":743336,"name":"Dmytro Isaev","orcid":"0000-0002-4126-2563","position":2,"is_corresponding":false},{"id":1188490,"name":"Аліна Савотченко","orcid":"0000-0001-5276-430X","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T01:21:22.368387Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}