{"doi":"10.70818/taj.v38i04.0471","title":"Correlation Between Lesion Localization and Severity of Post Stroke Depression","abstract":"<jats:p>Background: Post-stroke depression (PSD) is a common neuropsychiatric complication following cerebrovascular insult, where lesion localization significantly influences the severity and pattern of depressive symptoms among stroke survivors. Objective: This study aims to determine the correlation between specific lesion localization identified by neuroimaging and the severity of post-stroke depression using standardized psychometric assessment scales among stroke survivors in Bangladesh. Methods: A cross-sectional analytical study was conducted in the Department of Neuromedicine, Jessore Medical College, from July 2023 to June 2024. A total of 124 ischemic and hemorrhagic stroke survivors were screened using Patient Health Questionnaire-9 (PHQ-9) and MRI-based lesion mapping. Data were analyzed using Pearson’s correlation, one-way ANOVA, and multiple linear regression with p&lt;0.05 considered statistically significant. Results: The mean PHQ-9 score was 11.84 ± 5.26, indicating mild-to-moderate depression in 58.9% of subjects. Lesions localized in the left frontal cortex (n=34) showed the highest mean depression score (15.3 ± 4.1), followed by basal ganglia (n=22; 13.9 ± 3.8) and thalamic regions (n=18; 12.4 ± 3.6). Right hemispheric lesions (n=50) demonstrated significantly lower PHQ-9 means (9.7 ± 4.2) compared to left hemispheric lesions (n=74; 13.8 ± 4.9), t=3.89, p=0.001. Correlation analysis revealed a strong positive association between left anterior lesion volume and depression severity (r=0.62, p&lt;0.001). Multivariate regression identified lesion laterality (β=0.41, p=0.003) and lesion size (β=0.36, p=0.009) as independent predictors of PSD severity. Conclusion: Lesion localization, particularly in left frontal and subcortical regions, significantly correlates with post-stroke depression severity. Early identification through neuroimaging can enhance targeted psychiatric interventions and improve rehabilitation outcomes.</jats:p>","journal":"TAJ: Journal of Teachers Association","year":2025,"id":654436,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1707969,"name":"Md Amzad Hossain Sardar","orcid":null,"position":1,"is_corresponding":false},{"id":1707970,"name":"Md Amjad Hossain Pramanik","orcid":null,"position":2,"is_corresponding":false},{"id":1707967,"name":"Edrish Ali Akand","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Correlation Between Lesion Localization and Severity of Post Stroke Depression","abstract":"<jats:p>Background: Post-stroke depression (PSD) is a common neuropsychiatric complication following cerebrovascular insult, where lesion localization significantly influences the severity and pattern of depressive symptoms among stroke survivors. Objective: This study aims to determine the correlation between specific lesion localization identified by neuroimaging and the severity of post-stroke depression using standardized psychometric assessment scales among stroke survivors in Bangladesh. Methods: A cross-sectional analytical study was conducted in the Department of Neuromedicine, Jessore Medical College, from July 2023 to June 2024. A total of 124 ischemic and hemorrhagic stroke survivors were screened using Patient Health Questionnaire-9 (PHQ-9) and MRI-based lesion mapping. Data were analyzed using Pearson’s correlation, one-way ANOVA, and multiple linear regression with p&lt;0.05 considered statistically significant. Results: The mean PHQ-9 score was 11.84 ± 5.26, indicating mild-to-moderate depression in 58.9% of subjects. Lesions localized in the left frontal cortex (n=34) showed the highest mean depression score (15.3 ± 4.1), followed by basal ganglia (n=22; 13.9 ± 3.8) and thalamic regions (n=18; 12.4 ± 3.6). Right hemispheric lesions (n=50) demonstrated significantly lower PHQ-9 means (9.7 ± 4.2) compared to left hemispheric lesions (n=74; 13.8 ± 4.9), t=3.89, p=0.001. Correlation analysis revealed a strong positive association between left anterior lesion volume and depression severity (r=0.62, p&lt;0.001). Multivariate regression identified lesion laterality (β=0.41, p=0.003) and lesion size (β=0.36, p=0.009) as independent predictors of PSD severity. Conclusion: Lesion localization, particularly in left frontal and subcortical regions, significantly correlates with post-stroke depression severity. Early identification through neuroimaging can enhance targeted psychiatric interventions and improve rehabilitation outcomes.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19162232","pmcid":null,"openalex_id":"https://openalex.org/W4417138202","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.39860569,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://tajrmc.com/taj/article/download/471/611","host_type":"journal"},{"url":"https://tajrmc.com/taj/article/download/471/611","host_type":"publisher"},{"url":"https://doi.org/10.70818/taj.v38i04.0471","host_type":"journal"}],"fields_of_study":["Stroke Rehabilitation and Recovery","Spatial Neglect and Hemispheric Dysfunction","Acute Ischemic Stroke Management"],"mesh_terms":[],"keywords":["Lesion","Depression (economics)","Neuroimaging","Stroke (engine)","Correlation","Laterality","Frontal lobe","Severity of illness","Bayesian multivariate linear regression"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T06:38:05.758889Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}