{"doi":"10.64898/2026.06.26.732748","title":"HARMONY: A large-scale harmonized neuroimaging dataset for research on anxious misery disorders","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>Patterns of brain circuit dysfunction underlying depression and anxiety have been increasingly characterized, including dimensional and subtype variation. A key challenge is determining how such patterns generalize across populations and measurement frameworks. Here, we introduce HARMONY, a harmonized multimodal neuroimaging dataset supporting large-scale investigation of brain–behavior associations across symptom-defined dimensions. HARMONY integrates four Human Connectome Project–style Connectomes Related to Human Disease cohorts spanning adolescence to later adulthood and capturing anxious misery symptoms. The resource combines standardized HCP-style preprocessing, quality control, imaging-derived phenotypes, and harmonized symptom measures into a clinically enriched public dataset. Proof-of-concept analyses using HARMONY showed that pooling heterogeneous cohorts increased statistical power for detecting associations between imaging-derived phenotypes and anhedonia and depression severity. Effect sizes remained modest, consistent with symptom-based measures across heterogeneous samples. Functional imaging-derived phenotypes showed the strongest multivariate predictive performance. In summary, HARMONY provides a large multi-cohort resource for reproducible mental health neuroimaging research.</jats:p>","journal":null,"year":null,"id":635018,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10518,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":459160,"name":"Michael P. Harms","orcid":"0000-0001-7945-036X","position":1,"is_corresponding":false},{"id":463569,"name":"Petra Lenzini","orcid":"0009-0003-1446-8034","position":2,"is_corresponding":false},{"id":915389,"name":"Andrew Chen","orcid":"0000-0002-5082-7132","position":3,"is_corresponding":false},{"id":234075,"name":"Matthew F. Glasser","orcid":null,"position":4,"is_corresponding":false},{"id":1647256,"name":"Kassandra Hamilton","orcid":null,"position":5,"is_corresponding":false},{"id":1489702,"name":"Liangfang Li","orcid":"0009-0006-3472-8114","position":6,"is_corresponding":false},{"id":1177834,"name":"Xiaoke Luo","orcid":"0009-0006-8028-3822","position":7,"is_corresponding":false},{"id":819178,"name":"Michael Myers","orcid":"0000-0001-8525-6395","position":8,"is_corresponding":false},{"id":1647261,"name":"Adam R. 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HARMONY integrates four Human Connectome Project–style Connectomes Related to Human Disease cohorts spanning adolescence to later adulthood and capturing anxious misery symptoms. The resource combines standardized HCP-style preprocessing, quality control, imaging-derived phenotypes, and harmonized symptom measures into a clinically enriched public dataset. Proof-of-concept analyses using HARMONY showed that pooling heterogeneous cohorts increased statistical power for detecting associations between imaging-derived phenotypes and anhedonia and depression severity. Effect sizes remained modest, consistent with symptom-based measures across heterogeneous samples. Functional imaging-derived phenotypes showed the strongest multivariate predictive performance. In summary, HARMONY provides a large multi-cohort resource for reproducible mental health neuroimaging research.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42427512","pmcid":null,"openalex_id":"https://openalex.org/W7166855826","authors":[],"funders":[{"funder_name":"NIH","grant_id":"NIMH R01 MH132962","title":null},{"funder_name":"NIH","grant_id":"U01MH108168","title":null},{"funder_name":"NIH","grant_id":"U01MH109985","title":null},{"funder_name":"NIH","grant_id":"U01 MH109991","title":null},{"funder_name":"NIH","grant_id":"U01 MH110008","title":null},{"funder_name":"NIH","grant_id":"1S10OD025200-01A1","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH132962","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"RF1 MH132962","title":null}],"total_grants":8,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.64898/2026.06.26.732748","host_type":"repository"},{"url":"https://doi.org/10.64898/2026.06.26.732748","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.64898/2026.06.26.732748","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42427512","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13345329/","host_type":"repository"}],"fields_of_study":["Functional Brain Connectivity Studies","Mental Health Research Topics","Treatment of Major Depression"],"mesh_terms":[],"keywords":["Neuroimaging","Anhedonia","Human Connectome Project","Anxiety","Research Domain Criteria","Connectome","Cohort","Pooling"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:31:54.552943Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}