{"doi":"10.64898/2025.12.28.696768","title":"Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons","abstract":"Abstract Axon collaterals of type 1 molecular layer interneurons (MLI1s) contribute to pinceaux that engulf the initial segments of Purkinje cell (PC) axons and generate extracellular signals that ephaptically inhibit PCs. Here we show that a remarkably large number of MLI1s (∼50) contribute to each pinceau, and that this allows networks of synchronously firing MLI1s to use ephaptic signals to control the precise timing of PC firing in vivo .","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2025,"id":587383,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9504,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1503143,"name":"Elizabeth P Lackey","orcid":null,"position":1,"is_corresponding":false},{"id":1502346,"name":"Sevgi Öztürk","orcid":"0000-0002-5148-416X","position":2,"is_corresponding":false},{"id":1459380,"name":"Cole S. Gaynor","orcid":null,"position":3,"is_corresponding":false},{"id":1503144,"name":"Sean Ediger","orcid":null,"position":4,"is_corresponding":false},{"id":256210,"name":"Wei-Chung Allen Lee","orcid":"0000-0002-4618-295X","position":5,"is_corresponding":false},{"id":246024,"name":"Court Hull","orcid":"0000-0002-0360-8367","position":6,"is_corresponding":false},{"id":68573,"name":"Wade G. Regehr","orcid":"0000-0002-3485-8094","position":7,"is_corresponding":false},{"id":1071234,"name":"Aliya Norton","orcid":null,"position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T02:59:36.020030Z","pmid":"41509473","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}