{"doi":"10.62347/mvdh5025","title":"LAG-3 transcriptomic expression correlates linearly with other checkpoints, but not with clinical outcomes","abstract":null,"journal":"American Journal of Cancer Research","year":2024,"id":654697,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1708711,"name":"Jacob J Adashek","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"LAG-3 transcriptomic expression correlates linearly with other checkpoints, but not with clinical outcomes","abstract":"(moderate/low) RNA percentile level) was not a prognostic factor for overall survival (OS) in 272 immunotherapy-naïve patients with advanced/metastatic disease (Kaplan Meier analysis; P = 0.54). High LAG-3 levels correlated with longer OS after anti-PD-1/PD-L1-based checkpoint blockade (univariate (P = 0.003), but not multivariate analysis (hazard ratio, 95% confidence interval = 0.80 (0.46-1.40) (P = 0.44))); correlation with longer progression-free survival showed a weak univariate trend (P = 0.13). Taken together, these results suggest that high LAG-3 levels in and of themselves do not predict resistance to anti-PD-1/PD-L1 checkpoint blockade. Even so, since LAG-3 is often co-expressed with PD-1, PD-L1 and/or CTLA-4, selecting patients for combinations of checkpoint blockade based on immunomic co-expression patterns is a strategy that merits exploration.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38323282","pmcid":null,"openalex_id":"https://openalex.org/W4394749740","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"3P30CA023100-25S4","title":"Specialized Cancer Center Support Grant"},{"funder_name":"National Institutes of Health","grant_id":"5UG1CA233198-05","title":"MCW NCTN Lead Academic Participating Site"}],"total_grants":2,"fwci":1.0772,"citation_percentile":0.78766319,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://doi.org/10.62347/mvdh5025","host_type":"journal"},{"url":"https://doi.org/10.62347/mvdh5025","host_type":"publisher"},{"url":"https://e-century.us/files/ajcr/14/1/ajcr0154812.pdf","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38323282","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10839320","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10839320/pdf/ajcr0014-0368.pdf","host_type":"repository"}],"fields_of_study":["Cancer Immunotherapy and Biomarkers","Ferroptosis and cancer prognosis","Lung Cancer Treatments and Mutations","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":[],"keywords":["Immune checkpoint","Hazard ratio","Transcriptome","Medicine","Oncology","Internal medicine","Cancer","Proportional hazards model","Confidence interval","Univariate analysis","Ipilimumab","Immunotherapy","Multivariate analysis","Biology","Gene expression","Gene","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T07:54:42.722364Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}