{"doi":"10.61373/gp025l.0056","title":"Varying levels of interleukin 1 receptor antagonist (Il1rn) gene expression affect circulating leptin concentrations and fat distribution","abstract":"The relationship between leptin and interleukin 1 receptor antagonist (IL1RA) is critical to the understanding of obesity's low-grade chronic inflammatory state. IL1RA antagonizes the proinflammatory effects of IL1, dampens systemic inflammation markers, and in clinical trials improved glycemic control in type 2 diabetes. We show that leptin levels decreased relative to the number of Il1rn copies in mice overexpressing IL1RA; these mice have altered white fat distribution with decreased epididymal and retroperitoneal fat tissue masses. They also have increased IL1RA plasma levels and insulin sensitivity. Recombinant IL1RA may be a novel treatment strategy for metabolic syndrome by improving resistance to leptin and insulin.","journal":"Genomic psychiatry :","year":2025,"id":567887,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9612,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":349953,"name":"Claudio A. Mastronardi","orcid":"0000-0002-0777-9075","position":1,"is_corresponding":false},{"id":1472075,"name":"Gilberto Paz-Filho","orcid":"0000-0002-5940-4996","position":2,"is_corresponding":false},{"id":865862,"name":"Charmaine J. Simeonovic","orcid":"0000-0002-7161-5825","position":3,"is_corresponding":false},{"id":303750,"name":"Júlio Licinio","orcid":"0000-0001-6905-5884","position":4,"is_corresponding":false},{"id":436266,"name":"Ma‐Li Wong","orcid":"0000-0003-1512-3073","position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":null,"created_at":"2026-07-19T02:56:48.183032Z","pmid":"41908926","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}