{"doi":"10.6004/jnccn.2023.7080","title":"Group Coping Intervention in Patients With Chronic Graft-Versus-Host Disease: A Pilot Randomized Clinical Trial","abstract":"BACKGROUND: More than half the long-term survivors of allogeneic hematopoietic cell transplantation develop chronic graft-versus-host disease (GVHD), a debilitating inflammatory syndrome. Supportive interventions to assist survivors in coping with chronic GVHD are critically needed. PATIENTS AND METHODS: We conducted a pilot randomized clinical trial of a multidisciplinary group intervention (Horizons Program; n=39) versus minimally enhanced usual care (n=41) for patients with moderate or severe chronic GVHD. Horizons participants received 8 weekly sessions about GVHD and coping co-led by a transplant clinician and a behavioral health expert via a secure videoconferencing platform. Participants completed the following surveys before randomization, at 10 weeks, and at 18 weeks: Functional Assessment of Cancer Therapy-Bone Marrow Transplant Scale (FACT-BMT) for quality of life (QoL), Lee Symptom Scale for symptom burden, and Hospital Anxiety and Depression Scale-Depression Symptoms (HADS) for mood. The primary endpoint was feasibility (≥50% enrollment, ≥80% attendance in half the sessions for the Horizons arm only, and ≥80% retention). We also explored preliminary efficacy of the Horizons intervention on changes in patient-reported outcomes with linear mixed effects models and estimates of effect size at 10 weeks. RESULTS: We enrolled and registered 80 (67.2%) of 119 eligible patients (mean age, 62 years; 48.8% female). Of the participants in the Horizons Program, 84.6% attended at least half the sessions. Of registered participants, 91.3% completed assessment follow-ups (Horizons, 35/39 [89.7%]; minimally enhanced usual care, 38/41 [92.7%]). Horizons participants reported improvements in QoL (b = 2.24; d=0.53), anxiety symptoms (b = -0.10; d=0.34), and depression symptoms (b = -0.71; d=0.44) compared with participants who received minimally enhanced usual care. CONCLUSIONS: Participation in a multidisciplinary group intervention study was feasible for patients with chronic GVHD, with promising signals for improving QoL and mood. A full-scale efficacy trial is needed to confirm effects on patient-reported outcomes.","journal":"Journal of the National Comprehensive Cancer Network","year":2024,"id":429339,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9623,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":749006,"name":"Daniel Yang","orcid":null,"position":1,"is_corresponding":false},{"id":497884,"name":"Annemarie D. Jagielo","orcid":"0009-0003-8893-507X","position":2,"is_corresponding":false},{"id":498575,"name":"Jennifer D’Alotto","orcid":null,"position":3,"is_corresponding":false},{"id":1231979,"name":"Cathleen Poliquin","orcid":null,"position":4,"is_corresponding":false},{"id":418744,"name":"Dustin J. Rabideau","orcid":"0000-0002-3829-7079","position":5,"is_corresponding":false},{"id":1231443,"name":"Katherine Cronin","orcid":"0000-0003-2110-7635","position":6,"is_corresponding":false},{"id":715407,"name":"Richard Newcomb","orcid":"0000-0002-8251-6961","position":7,"is_corresponding":false},{"id":352805,"name":"Yibin Chen","orcid":"0009-0004-0423-5218","position":8,"is_corresponding":false},{"id":284134,"name":"Zachariah DeFilipp","orcid":"0000-0002-7994-8974","position":9,"is_corresponding":false},{"id":497885,"name":"Joseph A. Greer","orcid":"0000-0002-0979-4076","position":10,"is_corresponding":false},{"id":362068,"name":"Areej El‐Jawahri","orcid":"0000-0002-3556-1495","position":11,"is_corresponding":false},{"id":497882,"name":"Lara Traeger","orcid":"0000-0002-8175-5725","position":12,"is_corresponding":false},{"id":1231442,"name":"Ashley M. Nelson","orcid":"0000-0003-4148-1042","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T01:59:06.668462Z","pmid":"38394783","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}