{"doi":"10.6002/ect.2012.0094","title":"Mycophenolic Acid Pharmacokinetics Early After Kidney Transplant","abstract":null,"journal":"Experimental and Clinical Transplantation","year":2013,"id":634728,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1646364,"name":"Nazanin Honarbakhsh","orcid":null,"position":1,"is_corresponding":false},{"id":1646365,"name":"Mohammad Reza Rouini","orcid":null,"position":2,"is_corresponding":false},{"id":1646366,"name":"Mahboob Lesan-Pezeshki","orcid":null,"position":3,"is_corresponding":false},{"id":1646367,"name":"Mohammad Reza Javadi","orcid":null,"position":4,"is_corresponding":false},{"id":1646369,"name":"Iman Karimzadeh","orcid":null,"position":5,"is_corresponding":false},{"id":1646370,"name":"Niayesh Mohebbi","orcid":null,"position":6,"is_corresponding":false},{"id":152153,"name":"Kheirollah Gholami","orcid":null,"position":7,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mycophenolic Acid Pharmacokinetics Early After Kidney Transplant","abstract":"<h4>Objectives</h4>To determine the mycophenolic acid pharmacokinetic profile early after transplant in Iranian kidney graft recipients.<h4>Materials and methods</h4>A cross-sectional study was performed during 6 months in 31 patients who recently had kidney transplant and received fixed doses of mycophenolate mofetil (2 g/d). The plasma levels of mycophenolic acid were determined by high performance liquid chromatography.<h4>Results</h4>The mean first mycophenolic acid peak level was 10 ± 5 mg/L. The mean mycophenolic acid area under the curve was 26 ± 19 mgh/L and apparent clearance was 57 ± 55 L/h. The mycophenolic acid area under the curve values of only 8 patients (26%) were within the therapeutic range (30-60 mgh/L). The first, second, and third mycophenolic acid peak levels correlated significantly with mycophenolic acid area under the curve (P < .05). Mycophenolic acid concentration at 10 hours had the highest correlation with mycophenolic acid area under the curve (r=0.962; P < .05). No statistically significant differences were evident in the mean mycophenolic acid area under the curve between men and women.<h4>Conclusions</h4>There was a high degree of variation between different patients in mycophenolic acid pharmacokinetics early after kidney transplant.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23176542","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[],"fields_of_study":[],"mesh_terms":["Humans","Mycophenolic Acid","Immunosuppressive Agents","Kidney Transplantation","Transplantation, Homologous","Chromatography, High Pressure Liquid","Cross-Sectional Studies","Graft Rejection","Time Factors","Adult","Middle Aged","Iran","Female","Male","Young Adult"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:04:26.020395Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}