{"doi":"10.59448/jah.v1i1.2","title":"Associations between cumulative biological risk and subclinical atherosclerosis in middle- and older-aged South Asian immigrants in the United States","abstract":"INTRODUCTION: The aim of this study was to investigate associations between cumulative biological risk and subclinical atherosclerosis in South Asian immigrants. METHODS: Data from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study, including 858 participants at baseline (mean age = 56 [standard deviation = 9] years, 46% women). A cumulative biological risk score was derived using nine biomarkers across cardiovascular, immune, and metabolic systems with a possible score range of 0-9. Common and internal carotid artery intima media thickness (CIMT) and coronary artery calcium (CAC) were used as indicators of subclinical atherosclerosis. RESULTS: Higher cumulative biological risk score was significantly associated with higher common and internal CIMT and higher odds of CAC at baseline. The odds of new CAC after 5 years of follow-up were 31% higher per 1-point increase in cumulative biological risk score, and the higher cumulative biological risk score was also associated with CAC progression. CONCLUSIONS: Among South Asian immigrants, cumulative biological risk was directly associated with subclinical atherosclerosis and its progression.","journal":"Journal of Asian Health","year":2021,"id":210715,"datarank":0.2520681602488015,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.04412400608081792,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.04412400608081792,"corpus_percentile":40.341920012377194,"corpus_rank":7713,"citation_count":3,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8398,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":339098,"name":"Yichen Jin","orcid":"0000-0001-9207-2535","position":1,"is_corresponding":false},{"id":339101,"name":"Namratha R. Kandula","orcid":"0000-0003-2570-3426","position":2,"is_corresponding":false},{"id":245135,"name":"Alka M. Kanaya","orcid":"0000-0002-8903-1457","position":3,"is_corresponding":false},{"id":339099,"name":"Sameera A. Talegawkar","orcid":"0000-0003-2612-5728","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-18T23:52:12.491146Z","pmid":"35510154","pmcid":"PMC9062994","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}