{"doi":"10.59368/agingbio.20230009","title":"STAT1 Drives the Interferon-Like Response and Aging Hallmarks in Progeria","abstract":"calcitriol or baricitinib extend lifespan of progeria mice, and baricitinib alone or combined with a high-caloric/high-fat diet has a remarkable impact reducing skin, aortic, and adipose tissue degeneration. Critically, Stat1 haploinsufficiency reduces tissue degeneration/loss and extends lifespan of progeria mice, recapitulating baricitinib benefits. Our study unveils STAT1 as a driver of the IFN-like response and HGPS pathology and suggests that aberrant STAT1 signaling contributes to aging, providing new therapeutic possibilities for HGPS and other inflammation/IFN response-associated diseases.","journal":"PubMed","year":2023,"id":348021,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1089890,"name":"Rafael Cançado de Faria","orcid":"0000-0001-7984-5732","position":1,"is_corresponding":false},{"id":621802,"name":"Elena V. Shashkova","orcid":"0000-0002-8063-7671","position":2,"is_corresponding":false},{"id":574888,"name":"Colin A. Flaveny","orcid":"0000-0002-5391-715X","position":3,"is_corresponding":false},{"id":329354,"name":"Ángel Baldán","orcid":"0000-0003-0373-8492","position":4,"is_corresponding":false},{"id":258402,"name":"Kyle S. McCommis","orcid":"0000-0003-2381-1589","position":5,"is_corresponding":false},{"id":456308,"name":"Susana Gonzalo","orcid":"0000-0001-9631-1206","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:12:01.859977Z","pmid":"40255266","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}