{"doi":"10.5853/jos.2020.04280","title":"Decreased Basal Ganglia Volume in Cerebral Amyloid Angiopathy","abstract":"BACKGROUND AND PURPOSE: Cerebral amyloid angiopathy (CAA) is a common pathology of the leptomeningeal and cortical small vessels associated with hemorrhagic and non-hemorrhagic brain injury. Given previous evidence for CAA-related loss of cortical thickness and white matter volume, we hypothesized that CAA might also cause tissue loss in the basal ganglia. METHODS: We compared basal ganglia volumes expressed as a percentage of total intracranial volume (pBGV) of non-demented patients with sporadic and hereditary CAA to age-matched healthy control (HC) and Alzheimer's disease (AD) cohorts. RESULTS: Patients with sporadic CAA had lower pBGV (n=80, 1.16%±0.14%) compared to HC (n=80, 1.30%±0.13%, P<0.0001) and AD patients (n=80, 1.23%±0.11%, P=0.001). Similarly, patients with hereditary CAA demonstrated lower pBGV (n=25, 1.26%±0.17%) compared to their matched HC (n=25, 1.36%±0.15%, P=0.036). Using a measurement of normalized basal ganglia width developed for analysis of clinical-grade magnetic resonance images, we found smaller basal ganglia width in patients with CAA-related lobar intracerebral hemorrhage (ICH; n=93, 12.35±1.47) compared to age-matched patients with hypertension-related deep ICH (n=93, 13.46±1.51, P<0.0001) or HC (n=93, 15.45±1.22, P<0.0001). Within the sporadic CAA research cohort, decreased basal ganglia volume was independently correlated with greater cortical gray matter atrophy (r=0.45, P<0.0001), increased basal ganglia fractional anisotropy (r=-0.36, P=0.001), and worse performance on language processing (r=0.35, P=0.003), but not with cognitive tests of executive function or processing speed. CONCLUSIONS: These findings suggest an independent effect of CAA on basal ganglia tissue loss, indicating a novel mechanism for CAA-related brain injury and neurologic dysfunction.","journal":"Journal of Stroke","year":2021,"id":194823,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336053,"name":"Marco Pasi","orcid":"0000-0001-9976-2459","position":1,"is_corresponding":false},{"id":292620,"name":"Andreas Charidimou","orcid":"0000-0001-5891-337X","position":2,"is_corresponding":false},{"id":256544,"name":"Andrew D. Warren","orcid":"0000-0002-5832-8178","position":3,"is_corresponding":false},{"id":466210,"name":"Kristin Schwab","orcid":"0000-0001-5723-9109","position":4,"is_corresponding":false},{"id":229339,"name":"Alzheimer’s Disease Neuroimaging Initiative","orcid":null,"position":5,"is_corresponding":false},{"id":268233,"name":"Jonathan Rosand","orcid":"0000-0002-1014-9138","position":6,"is_corresponding":false},{"id":245370,"name":"Jeroen van der Grond","orcid":"0000-0002-0185-3158","position":7,"is_corresponding":false},{"id":245384,"name":"Mark A. van Buchem","orcid":"0000-0003-1881-1998","position":8,"is_corresponding":false},{"id":256550,"name":"Anand Viswanathan","orcid":"0000-0001-5398-1816","position":9,"is_corresponding":false},{"id":466211,"name":"M. Edip Gurol","orcid":"0000-0002-2169-4457","position":10,"is_corresponding":false},{"id":251653,"name":"Steven M. Greenberg","orcid":"0000-0003-1792-8887","position":11,"is_corresponding":false},{"id":452581,"name":"Panagiotis Fotiadis","orcid":"0000-0001-7287-9227","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T23:49:59.476757Z","pmid":"34102757","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}