{"doi":"10.5812/archcid.111405","title":"Plasmapheresis with Convalescent Plasma as a Rescue Therapy for COVID-19 Patients: A Case Series","abstract":"<jats:p>: On December 29, 2019, an epidemic of an infectious disease caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) was declared in Wuhan, China. The first case of COVID-19 in Iran (Qom Province) was reported in February 2020, and within a short period, the number of infected cases increased rapidly around the country. Evidence suggests that the levels of pro-inflammatory cytokines are high in critically ill patients, and there is a correlation between the high level of cytokines and the pathogenesis of COVID-19; consequently, COVID-19 may have complications, such as acute respiratory distress syndrome (ARDS) and even death. These inflammatory factors can lead to a cytokine storm, while counteracting this storm seems to be an effective therapeutic approach. In this case series, we reported two critically ill patients with COVID-19, undergoing plasmapheresis with convalescent plasma, corticosteroid therapy, and interferon administration.</jats:p>","journal":"Archives of Clinical Infectious Diseases","year":2022,"id":599924,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1537728,"name":"Seyed Hassan Adeli","orcid":"0000-0001-5970-7551","position":1,"is_corresponding":false},{"id":1537730,"name":"Akram Asghari","orcid":"0000-0001-6948-2675","position":2,"is_corresponding":false},{"id":1537731,"name":"Fateme Sadat Razavinia","orcid":null,"position":3,"is_corresponding":false},{"id":1537726,"name":"Jamshid Vafaeemanesh","orcid":"0000-0002-9063-2639","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Plasmapheresis with Convalescent Plasma as a Rescue Therapy for COVID-19 Patients: A Case Series","abstract":"<jats:p>: On December 29, 2019, an epidemic of an infectious disease caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) was declared in Wuhan, China. The first case of COVID-19 in Iran (Qom Province) was reported in February 2020, and within a short period, the number of infected cases increased rapidly around the country. Evidence suggests that the levels of pro-inflammatory cytokines are high in critically ill patients, and there is a correlation between the high level of cytokines and the pathogenesis of COVID-19; consequently, COVID-19 may have complications, such as acute respiratory distress syndrome (ARDS) and even death. These inflammatory factors can lead to a cytokine storm, while counteracting this storm seems to be an effective therapeutic approach. In this case series, we reported two critically ill patients with COVID-19, undergoing plasmapheresis with convalescent plasma, corticosteroid therapy, and interferon administration.</jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W4206436240","authors":[],"funders":[],"total_grants":0,"fwci":0.1991,"citation_percentile":0.47238024,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://brieflands.com/articles/archcid-111405.pdf","host_type":"journal"},{"url":"https://brieflands.com/articles/archcid-111405.pdf","host_type":"publisher"},{"url":"https://brieflands.com/articles/archcid-111405.html","host_type":"publisher"},{"url":"https://doi.org/10.5812/archcid.111405","host_type":"journal"}],"fields_of_study":["COVID-19 Clinical Research Studies","SARS-CoV-2 and COVID-19 Research","Long-Term Effects of COVID-19"],"mesh_terms":[],"keywords":["Cytokine storm","Plasmapheresis","ARDS","Medicine","Convalescent plasma","Coronavirus disease 2019 (COVID-19)","Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","Intensive care medicine","Acute respiratory distress","Immunology","Disease","Infectious disease (medical specialty)","Internal medicine","Lung","Antibody"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T11:41:46.857360Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}