{"doi":"10.58088/jjfa-c054","title":"Obesity indices in children with spastic cerebral palsy","abstract":"Cerebral palsy (CP) results from damage or malformation of the developing brain and is the most common physical disability of childhood with approximately 80% of all CP cases having some degree of skeletal muscle spasticity. Children with CP have difficulties with neuromuscular tasks, such as gait, posture and balance, are prone to skeletal muscle weakness and are less physically active than their typically developing peers. Children with CP present with a weak and underdeveloped musculoskeletal system that gets progressively worse throughout growth, potentially increasing the risk for development of musculoskeletal and cardiometabolic diseases. Importantly, mobility and gait function declines as children with CP age into their adult years which may act to exacerbate musculoskeletal pathology, excessive fat accumulation, frailty and chronic disease risk. This is supported by a higher prevalence of age-related chronic diseases and multimorbidity in adults with CP compared to the general population. However, considering age-related chronic diseases often get their roots in childhood, cardiometabolic disease risk and factors associated with cardiometabolic disease risk, such as musculoskeletal health and indices of obesity, have not been examined in children with CP. ☐ The first aim of this dissertation was to determine if ambulatory children with spastic CP have an altered fat distribution of the leg compared to typically developing children using magnetic resonance imaging at the mid-third of the leg. Compared to controls (n = 12), children with CP (n = 12) had no difference in total (p = 0.796) or subcutaneous (p = 0.868) fat, but had higher intermuscular (p = 0.036) and subfascial (p = 0.002) fat and intramuscular (p = 0.002) and tibia bone marrow (p = 0.004) fat concentration after statistically controlling for tibia length. These findings suggest that ambulatory children with spastic CP have an altered fat distribution profile of the leg that is favoring musculoskeletal depots as evidenced by no difference in total or subcutaneous fat, but higher fat infiltration of the skeletal muscle and bone marrow depots. ☐ The second aim of this dissertation was to determine the volume and fat concentration profile of the 11 individual leg muscles and how it relates to muscle strength in ambulatory children with spastic CP using magnetic resonance imaging along the length of the tibia and a Biodex dynamometer to assess muscle strength. Compared to controls (n = 14), children with CP (n = 14) had lower volume of all muscles (all p < 0.05), except for the marginally insignificant peroneus longus (p = 0.052), ranging from 27 % (peroneus longus) to 44 % (tibialis anterior) and higher intramuscular fat of all muscles (all p < 0.05) ranging from 4.4 (tibialis posterior) to 10.1 (soleus) percentile units. The slopes for tibia length regressed on flexor digitorum longus volume and tibialis anterior volume were significantly different between groups (interaction, p = 0.040 and 0.005, respectively). There were positive relationships between plantar flexion strength regressed on gastrocnemius and soleus volume and dorsi flexion strength regressed on tibialis anterior volume in children with CP and controls (r2 = 0.32 to 0.71, all p < 0.05). When intramuscular fat concentration was removed from muscle volume (corrected muscle volume), the relationships became slightly stronger (r2 = 0.37 to 0.77, all p < 0.05). For all the uncorrected and corrected muscle volume-strength relationships, there was a significant difference in the y-intercept between groups, but not the slope. These findings suggest that ambulatory children with spastic CP have smaller muscles that are highly infiltrated with fat and have weaker muscle strength per unit of muscle volume. The higher intramuscular fat of the gastrocnemius, soleus and tibialis anterior is contributing to muscle weakness in ambulatory children with spastic CP; albeit, to a small extent. ☐ The third aim of","journal":"Library, Museums and Press - UDSpace (University of Delaware)","year":2024,"id":492864,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":409162,"name":"Daniel G. Whitney","orcid":"0000-0003-2132-1527","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:08:56.210382Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}