{"doi":"10.5754/hge12059","title":"Factors Contributing to the Overall Survival in Patients with Hepatocellular Carcinoma Treated by Sorafenib","abstract":null,"journal":"Hepatogastroenterology","year":2012,"id":625064,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1616121,"name":"Hitoshi Mochizuki","orcid":null,"position":1,"is_corresponding":false},{"id":1616122,"name":"Yuji Hoshino","orcid":null,"position":2,"is_corresponding":false},{"id":1616123,"name":"Satoshi Kawakami","orcid":null,"position":3,"is_corresponding":false},{"id":1616124,"name":"Toru Kuno","orcid":null,"position":4,"is_corresponding":false},{"id":1616125,"name":"Yoshimitsu Fukasawa","orcid":null,"position":5,"is_corresponding":false},{"id":1616126,"name":"Fumihiko Iwamoto","orcid":null,"position":6,"is_corresponding":false},{"id":1616127,"name":"Sumio Hirose","orcid":null,"position":7,"is_corresponding":false},{"id":900699,"name":"Takashi Yoshida","orcid":"0000-0003-1119-312X","position":8,"is_corresponding":false},{"id":1616128,"name":"Kenji Hosoda","orcid":null,"position":9,"is_corresponding":false},{"id":1616129,"name":"Youji Suzuki","orcid":null,"position":10,"is_corresponding":false},{"id":1616130,"name":"Kazuhiko Hosoda","orcid":null,"position":11,"is_corresponding":false},{"id":1616131,"name":"Yuichiro Kojima","orcid":null,"position":12,"is_corresponding":false},{"id":1616132,"name":"Yuichi Hirose","orcid":null,"position":13,"is_corresponding":false},{"id":1616133,"name":"Kuniaki Shindou","orcid":null,"position":14,"is_corresponding":false},{"id":1616134,"name":"Masanori Matsuda","orcid":null,"position":15,"is_corresponding":false},{"id":1616135,"name":"Syoji Yagawa","orcid":null,"position":16,"is_corresponding":false},{"id":1529957,"name":"Akio Tawara","orcid":null,"position":17,"is_corresponding":false},{"id":1024299,"name":"Masashi Kobayashi","orcid":"0000-0001-5401-9581","position":18,"is_corresponding":false},{"id":1616136,"name":"Toshiyuki Konishi","orcid":null,"position":19,"is_corresponding":false},{"id":1616137,"name":"Takahisa Yamazaki","orcid":null,"position":20,"is_corresponding":false},{"id":1616138,"name":"Seiichiro Takahashi","orcid":null,"position":21,"is_corresponding":false},{"id":334244,"name":"Hideki Fujii","orcid":"0000-0003-1267-9623","position":22,"is_corresponding":false},{"id":925108,"name":"Nobuyuki Enomoto","orcid":null,"position":23,"is_corresponding":false},{"id":1181551,"name":"Masao Omata","orcid":"0000-0001-7977-1497","position":24,"is_corresponding":false},{"id":1616120,"name":"Yuya Tsukui","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Factors Contributing to the Overall Survival in Patients with Hepatocellular Carcinoma Treated by Sorafenib","abstract":"BACKGROUND/AIMS: In both SHARP and Asia-Pacific Study, sorafenib was proved to improve the overall survival of the patients with hepatocellular carcinoma. However, factors contributing to the improvement of overall survival of the patients treated by sorafenib have not been fully evaluated. In this study, patient-derived, background liver disease-derived and tumor-derived factors before treatment were evaluated whether they have contributed to the improvement of the overall survival. METHODOLOGY: Forty-seven cases with HCC treated by sorafenib between Sept 2009 and Feb 2011 were included in this analysis. The survival of these cases was analyzed by Kaplan-Meier Method. Factors used for univariate analysis were two patient-derived parameters, two background liver disease-derived, five tumor-derived. Factors related to the over-all survival were analyzed by multivariate analysis using Cox regression model. RESULTS: In the multivariate analysis, only background liver disease-derived parameter Child-Pugh class A vs. B, (p=0.007, HR=0.21 (0.07-0.65)) was significant. No other parameters including tumor-derived factors were statistically significant by multivariate analysis. CONCLUSIONS: We undertook the statistical analysis on the three categories. Surprisingly, no tumor derived parameter contributed to the overall survival. Background liver disease-derived parameter rather than tumor-derived parameter was found to define the prognosis of patients with advanced HCC treated by sorafenib.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22497953","pmcid":null,"openalex_id":"https://openalex.org/W1992278374","authors":[],"funders":[],"total_grants":0,"fwci":0.7164,"citation_percentile":0.69172607,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":3},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.5754/hge12059","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22497953","host_type":"repository"}],"fields_of_study":["Hepatocellular Carcinoma Treatment and Prognosis","Cholangiocarcinoma and Gallbladder Cancer Studies","Cancer Research and Treatment"],"mesh_terms":["Sorafenib","Adult","Aged","Aged, 80 and over","Antineoplastic Agents","Female","Carcinoma, Hepatocellular","Humans","Japan","Liver Neoplasms","Male","Middle Aged","Niacinamide","Phenylurea Compounds","Retrospective Studies","Time Factors","Multivariate Analysis","Proportional Hazards Models","Treatment Outcome","Protein Kinase Inhibitors","Kaplan-Meier Estimate"],"keywords":["Sorafenib","Hepatocellular carcinoma","Medicine","Internal medicine","Multivariate analysis","Proportional hazards model","Survival analysis","Oncology","Univariate analysis","Liver cancer","Univariate","Multivariate statistics","Gastroenterology","Overall survival","Statistics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T05:42:47.973100Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}