{"doi":"10.5631/jibirin.76.1435","title":"","abstract":null,"journal":"Practica Oto-Rhino-Laryngologica","year":1983,"id":623052,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1610085,"name":"Kazuo Uede","orcid":null,"position":1,"is_corresponding":false},{"id":1610086,"name":"Toshiyuki Ono","orcid":null,"position":2,"is_corresponding":false},{"id":1030833,"name":"Susumu Nakae","orcid":"0000-0002-8988-0256","position":3,"is_corresponding":false},{"id":1610087,"name":"Yoshiaki Hirasugi","orcid":null,"position":4,"is_corresponding":false},{"id":206568,"name":"Hitoshi Saito","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":null,"abstract":"Comparative ototoxicity and nephrotoxicity studies of gentamicin between 60-minute intravenous infusion and intramuscular administration were carried out using a total of 36 rabbits. The following results were obtained:At the dose of 30mg/kg, there was no difference in ototoxicity and nephrotoxicity between 60-minute intravenous infusion and intramuscular administration.At the dose of 40mg/kg, almost similar ototoxicity was observed via both administration routes. However, deaths that are considered attributable to nephrotoxicity were found in more animals in the 60-minute intravenous infusion group than in the intramuscular administration group. This result indicates that the risk of ototoxicity may be secondarily increased by a retarded excretion of gentamicin.The dose of 40mg/kg was considered to be the threshold to develop significant nephrotoxicity and ototoxicity by 60-minute intravenous infusion.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":"https://openalex.org/W4235525832","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.31738993,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jibirin1925/76/5/76_5_1435/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/jibirin1925/76/5/76_5_1435/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.5631/jibirin.76.1435","host_type":"journal"}],"fields_of_study":["Molecular Sensors and Ion Detection","Neuroscience and Neuropharmacology Research","Nicotinic Acetylcholine Receptors Study"],"mesh_terms":[],"keywords":["Ototoxicity","Nephrotoxicity","Medicine","Intramuscular injection","Gentamicin","Anesthesia","Aminoglycoside","Excretion","Pharmacology","Toxicity","Antibiotics","Internal medicine","Chemotherapy","Chemistry","Cisplatin"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T22:08:55.738435Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}