{"doi":"10.5607/en.2016.25.3.103","title":"Adult Neurogenesis and Gliogenesis: Possible Mechanisms for Neurorestoration","abstract":null,"journal":"Experimental Neurobiology","year":2016,"id":48018,"datarank":1.5948305316299598,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":1.0238311581644117,"self_endowment_contribution":0.5709993734655481,"citer_contribution":1.0238311581644117,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":43,"citers_with_citation_signal":38,"citers_with_endowment":38,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":224964,"name":"Willem Henskens","orcid":null,"position":1,"is_corresponding":false},{"id":224965,"name":"Emma Schofield","orcid":null,"position":2,"is_corresponding":false},{"id":224966,"name":"Woojin S. Kim","orcid":null,"position":3,"is_corresponding":false},{"id":224967,"name":"YuHong Fu","orcid":null,"position":4,"is_corresponding":false},{"id":224963,"name":"Zoltán Rusznák","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Adult Neurogenesis and Gliogenesis: Possible Mechanisms for Neurorestoration","abstract":"The subgranular zone (SGZ) and subventricular zone (SVZ) are developmental remnants of the germinal regions of the brain, hence they retain the ability to generate neuronal progenitor cells in adult life. Neurogenesis in adult brain has an adaptive function because newly produced neurons can integrate into and modify existing neuronal circuits. In contrast to the SGZ and SVZ, other brain regions have a lower capacity to produce new neurons, and this usually occurs via parenchymal and periventricular cell genesis. Compared to neurogenesis, gliogenesis occurs more prevalently in the adult mammalian brain. Under certain circumstances, interaction occurs between neurogenesis and gliogenesis, facilitating glial cells to transform into neuronal lineage. Therefore, modulating the balance between neurogenesis and gliogenesis may present a new perspective for neurorestoration, especially in diseases associated with altered neurogenesis and/or gliogenesis, cell loss, or disturbed homeostasis of cellular constitution. The present review discusses important neuroanatomical features of adult neurogenesis and gliogenesis, aiming to explore how these processes could be modulated toward functional repair of the adult brain.","is_dataset_classified":null,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27358578","pmcid":"PMC4923354","openalex_id":"https://openalex.org/W2468147353","authors":[],"funders":[{"funder_name":"Australian Research Council Centre of Excellence for Integrative Brain Function","grant_id":"CE140100007","title":"ARC Centres of Excellence - Grant ID: CE140100007"},{"funder_name":"National Health and Medical Research Council","grant_id":"APP1086643","title":null},{"funder_name":"National Health and Medical Research Council","grant_id":"APP1086083","title":null},{"funder_name":"National Institute of Mental Health of the National Institutes of Health","grant_id":"1U01MH105971-01","title":"Towards quantitative cell type-based mapping of the whole mouse brain"},{"funder_name":"NIMH NIH HHS","grant_id":"U01 MH105971","title":null},{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"1086643","title":"High Resolution MRI Atlas of the Rat Brain"},{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"1086083","title":"A 3D Cross-Modality Atlas of the Human Brainstem for Scientists and Clinicians"}],"total_grants":7,"fwci":3.0348,"citation_percentile":0.91723666,"influential_citations":2,"citation_trend":[{"year":2016,"count":2},{"year":2017,"count":3},{"year":2018,"count":5},{"year":2019,"count":7},{"year":2020,"count":6},{"year":2021,"count":9},{"year":2022,"count":5},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"bronze","license":"CC BY NC","oa_locations":[{"url":"https://www.en-journal.org/journal/download_pdf.php?uid=301","host_type":"journal"},{"url":"https://www.en-journal.org/journal/download_pdf.php?uid=301","host_type":"BRONZE"},{"url":"https://www.en-journal.org/journal/download_pdf.php?uid=301","host_type":"publisher"},{"url":"http://synapse.koreamed.org/pdf/10.5607/en.2016.25.3.103","host_type":"publisher"},{"url":"http://synapse.koreamed.org/DOIx.php?id=10.5607/en.2016.25.3.103","host_type":"publisher"},{"url":"https://doi.org/10.5607/en.2016.25.3.103","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27358578","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4923354","host_type":"repository"},{"url":"http://doi.org/10.5607/en.2016.25.3.103","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4923354","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4923354?pdf=render","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/pmc4923354?pdf=render","host_type":""},{"url":"http://dx.doi.org/10.5607/en.2016.25.3.103","host_type":""},{"url":"https://dx.doi.org/10.5607/en.2016.25.3.103","host_type":""},{"url":"https://hdl.handle.net/20.500.14802/27443","host_type":""},{"url":"https://doi.org/https://doi.org/10.5607/en.2016.25.3.103","host_type":""}],"fields_of_study":["Neurogenesis and neuroplasticity mechanisms","Anesthesia and Neurotoxicity Research","Diet and metabolism studies","Biology","Medicine","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Gliogenesis","Neurogenesis","Neuroscience","Medicine","Psychology","Biology","Neural stem cell","Cell biology","Stem cell","Aging","Neurodegeneration","Neurorestoration","Review Article"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-18T20:17:28.129183Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}