{"doi":"10.5603/cj.a2020.0187","title":"Factors and outcomes associated with improved left ventricular systolic function in patients with cardiomyopathy","abstract":"BACKGROUND: Many patients in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) had a significant improvement (> 10%) in the left ventricular ejection fraction (LVEF) during the course of the study, but the factors and outcomes associated with such improvement are uncertain. METHODS: We examined factors and rates of mortality, cause-specific mortality, and implantable cardioverter-defibrillator (ICD) shocks associated with improvement in LVEF by analyzing patients in the SCD-HeFT who were randomized to placebo or an ICD and who had an LVEF checked during follow-up. RESULTS: During a median follow-up of 3.99 years, of 837 patients who had at least two follow-up LVEF measurements, 276 (33%) patients had > 10% improvement in LVEF and 561 (67%) patients had no significant change in LVEF. Factors significantly associated with LVEF improvement included female sex, white race, history of hypertension, a QRS duration < 120 ms, and beta-blocker use. Improvement in LVEF was associated with a significant improvement in survival. There was no significant association between improvement in LVEF and cause-specific death, but there was a significant association between improvement in LVEF and reduced risk of receiving appropriate ICD shocks. CONCLUSIONS: About a third of patients in this analysis, who were randomized to placebo or an ICD in SCD-HeFT, had a significant improvement in LVEF during follow-up; improvement in LVEF was associated with improved survival but not with cause-specific death, and with decreased likelihood of receiving appropriate ICD shocks.","journal":"Cardiology Journal","year":2021,"id":210884,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":800398,"name":"Lurdes Y. T. Inoue","orcid":null,"position":1,"is_corresponding":false},{"id":799772,"name":"Qijun Li","orcid":"0000-0003-0635-9025","position":2,"is_corresponding":false},{"id":71410,"name":"Gust H. Bardy","orcid":null,"position":3,"is_corresponding":false},{"id":799773,"name":"Kerry Lee","orcid":"0000-0002-8296-8028","position":4,"is_corresponding":false},{"id":85284,"name":"Jeanne E. Poole","orcid":"0000-0002-8481-7389","position":5,"is_corresponding":false},{"id":85283,"name":"Daniel B. Mark","orcid":"0000-0001-6340-8087","position":6,"is_corresponding":false},{"id":48674,"name":"Zainab Samad","orcid":"0000-0003-2422-3199","position":7,"is_corresponding":false},{"id":383115,"name":"Daniel J. Friedman","orcid":"0000-0001-5791-1954","position":8,"is_corresponding":false},{"id":800399,"name":"Daniel Fishbein","orcid":null,"position":9,"is_corresponding":false},{"id":606103,"name":"Gillian D Sanders","orcid":null,"position":10,"is_corresponding":false},{"id":337350,"name":"Sana M. Al‐Khatib","orcid":"0000-0002-3561-0146","position":11,"is_corresponding":false},{"id":354432,"name":"Dylan Scott Eiger","orcid":"0000-0001-9572-6282","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-18T23:52:16.049481Z","pmid":"33438181","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}