{"doi":"10.5588/ijtldopen.23.0283","title":"Preference for daily (1HP) vs. weekly (3HP) isoniazid-rifapentine among people living with HIV in Uganda","abstract":"BACKGROUND: Both 1 month of daily (1HP) and 3 months of weekly (3HP) isoniazid-rifapentine are recommended as short-course regimens for TB prevention among people living with HIV (PLHIV). We aimed to assess acceptability and preferences for 1HP vs. 3HP among PLHIV. METHODS: In a cross-sectional survey among PLHIV at an HIV clinic in Kampala, Uganda, participants were randomly assigned to a hypothetical scenario of receiving 1HP or 3HP. Participants rated their level of perceived intention and confidence to complete treatment using a 0-10 Likert scale, and chose between 1HP and 3HP. RESULTS: Among 429 respondents (median age: 43 years, 71% female, median time on ART: 10 years), intention and confidence were rated high for both regimens. Intention to complete treatment was rated at least 7/10 by 92% (189/206 randomized to 1HP) and 93% (207/223 randomized to 3HP). Respectively 86% (178/206) and 93% (208/223) expressed high confidence to complete treatment. Overall, 81% (348/429) preferred 3HP over 1HP. CONCLUSIONS: Both 1HP and 3HP were highly acceptable regimens, with 3HP preferred by most PLHIV. Weekly, rather than daily, dosing appears preferable to shorter duration of treatment, which should inform scale-up and further development of short-course regimens for TB prevention.","journal":"IJTLD OPEN","year":2024,"id":475053,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9586,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":883317,"name":"Hélène E. Aschmann","orcid":"0000-0003-1234-4321","position":1,"is_corresponding":false},{"id":413974,"name":"Jillian L. Kadota","orcid":"0000-0003-4568-8681","position":2,"is_corresponding":false},{"id":1177205,"name":"Jane Nakimuli","orcid":"0009-0001-2701-2330","position":3,"is_corresponding":false},{"id":511679,"name":"Fred Welishe","orcid":null,"position":4,"is_corresponding":false},{"id":1177501,"name":"Juliet Kakeeto","orcid":null,"position":5,"is_corresponding":false},{"id":1312236,"name":"C. Namale","orcid":null,"position":6,"is_corresponding":false},{"id":1177206,"name":"Lydia Akello","orcid":"0009-0009-4013-9692","position":7,"is_corresponding":false},{"id":1177207,"name":"Anne Nakitende","orcid":"0000-0001-8198-6681","position":8,"is_corresponding":false},{"id":387482,"name":"Christopher A. Berger","orcid":"0000-0002-0034-7544","position":9,"is_corresponding":false},{"id":315467,"name":"Achilles Katamba","orcid":"0000-0002-2347-4183","position":10,"is_corresponding":false},{"id":1189108,"name":"Josephine Tumuhamye","orcid":"0000-0001-5733-7227","position":11,"is_corresponding":false},{"id":363888,"name":"Noah Kiwanuka","orcid":"0000-0003-2471-9290","position":12,"is_corresponding":false},{"id":315468,"name":"David W. Dowdy","orcid":"0000-0003-0481-7475","position":13,"is_corresponding":false},{"id":315466,"name":"Adithya Cattamanchi","orcid":"0000-0002-6553-2601","position":14,"is_corresponding":false},{"id":328477,"name":"Fred C. Semitala","orcid":"0000-0002-0624-7640","position":15,"is_corresponding":false},{"id":511219,"name":"Allan Musinguzi","orcid":"0000-0001-9941-6433","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T02:06:16.992586Z","pmid":"38966690","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}