{"doi":"10.5588/ijtldopen.23.0053","title":"Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South Africa","abstract":"INTRODUCTION: Children with underlying comorbidities and infants are most severely affected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, including in low- and middle-income countries with a high prevalence of HIV and TB. We describe the clinical presentation of SARS-CoV-2 infection in children during the Omicron wave, in Cape Town, South Africa. METHODS: We analysed routine care data from a prospective cohort of children aged 0-13 years, with a positive SARS-CoV-2 real-time reverse-transcription polymerase chain reaction (rRT-PCR) or SARS-CoV-2 antigen test, admitted to Tygerberg Hospital between 1 November 2021 until 1 March 2022. Risk factors for severity of disease were assessed. RESULTS: Ninety-five children tested positive for SARS-CoV-2, of whom 87 (91.6%) were symptomatic. Clinical data were available for 86 children. The median age was 11 months (IQR 3.0-60.0), 37 (43.0%) were females, 21 (24.7%) were HIV-exposed and 7 (8.1%) were living with HIV (CLHIV). In total, 44 (51.2%) children had at least one underlying comorbidity. TB co-infection was seen in 11 children, 6 children were newly diagnosed and 5 children were already on TB treatment at the time of admission. CONCLUSION: There was no evidence of more severe disease in children living with HIV or TB.","journal":"IJTLD OPEN","year":2024,"id":448215,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8481,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1232341,"name":"Isabelle Dewandel","orcid":"0000-0003-1097-9059","position":1,"is_corresponding":false},{"id":328855,"name":"Andrew Redfern","orcid":"0000-0002-6949-6249","position":2,"is_corresponding":false},{"id":1267259,"name":"CA McKenzie","orcid":null,"position":3,"is_corresponding":false},{"id":328854,"name":"Juanita Lishman","orcid":"0000-0003-0743-6766","position":4,"is_corresponding":false},{"id":231954,"name":"Lilly M. Verhagen","orcid":"0000-0002-3451-9201","position":5,"is_corresponding":false},{"id":328861,"name":"Mathilda Claassen","orcid":"0000-0002-6308-4438","position":6,"is_corresponding":false},{"id":1266850,"name":"Shawn Wilson","orcid":"0000-0002-1123-0165","position":7,"is_corresponding":false},{"id":334962,"name":"Rory Dunbar","orcid":"0000-0003-1852-5940","position":8,"is_corresponding":false},{"id":1267260,"name":"C. Bosch","orcid":null,"position":9,"is_corresponding":false},{"id":69675,"name":"Gert U. van Zyl","orcid":"0000-0003-3021-5101","position":10,"is_corresponding":false},{"id":259094,"name":"Wolfgang Preiser","orcid":"0000-0002-0254-7910","position":11,"is_corresponding":false},{"id":328862,"name":"Pierre Goussard","orcid":"0000-0003-1146-1307","position":12,"is_corresponding":false},{"id":328863,"name":"Helena Rabie","orcid":"0000-0001-6336-2963","position":13,"is_corresponding":false},{"id":328853,"name":"Marieke M. van der Zalm","orcid":"0000-0002-8787-9139","position":14,"is_corresponding":false},{"id":1267258,"name":"C. Bekker","orcid":null,"position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T02:02:08.018689Z","pmid":"38919411","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}