{"doi":"10.5588/ijtld.22.0654","title":"Cost-effectiveness of expanded latent TB infection testing and treatment: Lynn City, Massachusetts, USA","abstract":"BACKGROUND: Between October 2016 and March 2019, Lynn Community Health Center in Massachusetts implemented a targeted latent TB infection testing and treatment (TTT) program, increasing testing from a baseline of 1,200 patients tested to an average of 3,531 patients tested, or 9% of the population per year. METHODS: We compared pre-implementation TTT, represented by the first two quarters of implementation data, to TTT, represented by 12 quarters of data. Time, diagnostic, and laboratory resources were estimated using micro-costing. Other cost and testing data were obtained from the electronic health record, pharmaceutical claims, and published reimbursement rates. A Markov cohort model estimated future health outcomes and cost-effectiveness from a societal perspective in 2020 US dollars. Monte Carlo simulation generated 95% uncertainty intervals. RESULTS: The TTT program exhibited extended dominance over baseline pre-intervention testing and had an incremental cost-effectiveness ratio (ICER) of US$52,603 (US$22,008â–“US$95,360). When compared to baseline pre-TTT testing, the TTT program averted an estimated additional 7.12 TB cases, 3.49 hospitalizations, and 0.16 deaths per lifetime cohort each year. CONCLUSIONS: TTT was more cost-effective than baseline pre-implementation testing. Lynn Community Health Centerâ–™s experience can help inform other clinics considering expanding latent TB infection testing.","journal":"The International Journal of Tuberculosis and Lung Disease","year":2024,"id":441726,"datarank":0.4246051525137733,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.09502146591334032,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.09502146591334032,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":4,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6983,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":430030,"name":"Rachel Yelk Woodruff","orcid":"0000-0002-7467-2622","position":1,"is_corresponding":false},{"id":1255230,"name":"D. M. Sanderson","orcid":null,"position":2,"is_corresponding":false},{"id":1255231,"name":"C.F. Fisher","orcid":null,"position":3,"is_corresponding":false},{"id":325517,"name":"Suzanne M. Marks","orcid":"0000-0003-3024-1940","position":4,"is_corresponding":false},{"id":1255232,"name":"VS Green","orcid":null,"position":5,"is_corresponding":false},{"id":546299,"name":"Andrew Tibbs","orcid":null,"position":6,"is_corresponding":false},{"id":364037,"name":"Andrew Hill","orcid":"0000-0002-7418-6456","position":7,"is_corresponding":false},{"id":1255233,"name":"Hanna H Haptu","orcid":null,"position":8,"is_corresponding":false},{"id":306787,"name":"David D. McManus","orcid":"0000-0002-9343-6203","position":9,"is_corresponding":false},{"id":1254779,"name":"Ranjani K. Paradise","orcid":"0009-0002-6385-9384","position":10,"is_corresponding":false},{"id":1255234,"name":"Ceylon Auguste-Nelson","orcid":null,"position":11,"is_corresponding":false},{"id":545678,"name":"Jennifer Cochran","orcid":"0000-0003-1939-4233","position":12,"is_corresponding":false},{"id":470660,"name":"Garrett R. Beeler Asay","orcid":null,"position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:01:11.152920Z","pmid":"38178297","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}