{"doi":"10.55544/jrasb.1.4.8","title":"Clinicopathology & Molecular Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) in Children - Insights from Past, Present, and Future Directions","abstract":"Diffuse Intrinsic Pontine Glioma, or DIPG, is a rare, highly aggressive, heterogeneous group of brainstem tumors. Around 10-20% of primary brain tumors are considered pediatric brain tumors, of which 10-15% are diffuse brainstem tumors. It is considered untreatable and surgically unremovable due to its intrinsic position within the brain. Over the years, applying radiotherapy and chemotherapy has not shown a better outcome. However, gene-targeted therapy has proven successful, but it is still in the developing phase. This article covers the various aspects of DIPG, from clinical and molecular definitions to a vision for a universally accepted novel approach to beat this severe condition by joining fundamental science and translational research.","journal":"Journal for Research in Applied Sciences and Biotechnology","year":2022,"id":295981,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":982186,"name":"Arupam Biswas","orcid":"0000-0001-9538-2192","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T00:31:12.531553Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}