{"doi":"10.5551/jat.65313","title":"Genetic Evidence of Causal Effect between C1q/TNF-Related Protein-1 and Atherosclerosis: a Bidirectional and Multivariate Mendelian Randomization Study","abstract":null,"journal":"Journal of Atherosclerosis and Thrombosis","year":2025,"id":590857,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":660199,"name":"Jia Huang","orcid":"0000-0002-5633-6561","position":1,"is_corresponding":false},{"id":1511685,"name":"Yueying Chen","orcid":null,"position":2,"is_corresponding":false},{"id":1380681,"name":"Nan Jiang","orcid":"0000-0002-8849-7976","position":3,"is_corresponding":false},{"id":1159854,"name":"Yuxin Guo","orcid":"0000-0002-6082-4218","position":4,"is_corresponding":false},{"id":23437,"name":"Ji Zhang","orcid":"0000-0002-9274-1767","position":5,"is_corresponding":false},{"id":1511686,"name":"Shiyuan Zhou","orcid":null,"position":6,"is_corresponding":false},{"id":1511688,"name":"Huan Pu","orcid":null,"position":7,"is_corresponding":false},{"id":612806,"name":"Qing Deng","orcid":"0000-0001-9835-6889","position":8,"is_corresponding":false},{"id":455368,"name":"Bo Hu","orcid":"0000-0003-0606-7639","position":9,"is_corresponding":false},{"id":888284,"name":"Qing Zhou","orcid":"0000-0003-2565-3721","position":10,"is_corresponding":false},{"id":1511684,"name":"Juhong Pan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genetic Evidence of Causal Effect between C1q/TNF-Related Protein-1 and Atherosclerosis: a Bidirectional and Multivariate Mendelian Randomization Study","abstract":"AIMS: To investigate the causal relationship between C1q/TNF-related protein-1 (CTRP1) and atherosclerosis across various vascular sites, informed by studies connecting CTRP1 to coronary artery disease. METHODS: Summary statistics of CTRP1 from the available genome-wide association studies and atherosclerosis in classic vascular sites (including cerebral, coronary, and other arteries) from the FinnGen biobank were extracted for a primary MR analysis, and the analysis was replicated using Ischemic Stroke cohort (large artery atherosclerosis) for validation. The inverse variance-weighted method was used for primary assessment. Sensitivity analysis was performed by Cochrane's Q test and leave-one-out analysis. Potential pleiotropic effects were assessed by MR-Egger intercept and MR-PRESSO global test. Additionally, multivariable MR (MVMR) analysis was performed to investigate the independent effect of CTRP1 on atherosclerosis after removing confounding factors. RESULTS: Reliable causal evidence was found for CTRP1 involvement in three atherosclerosis endpoints: causal effects of CTRP1 on cerebral atherosclerosis (OR=1.31, CI:1.04-1.66; FDR_P=0.0222)], coronary atherosclerosis (OR=1.13, CI: 1.08-1.19; FDR_P=2.86e-07), and atherosclerosis at other sites (OR=1.06, CI:1.02-1.11; FDR_P=0.0125). The validation cohort further confirmed its causal effect on large-artery atherosclerosis (OR=1.10, CI:1.03-1.18; FDR_P=0.0115). The reverse MR analysis did not support the causal effect of atherosclerosis on CTRP1. Moreover, the MVMR analysis, adjusting for confounders (CTRP3, CTRP5, and CTRP9A), highlighted a significant independent causal effect of CTRP1 remaining on atherosclerosis. CONCLUSION: CTRP1 may represent a promising target for preventing and treating systemic atherosclerosis.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39617479","pmcid":"PMC12055506","openalex_id":"https://openalex.org/W4404875725","authors":[],"funders":[],"total_grants":0,"fwci":0.3151,"citation_percentile":0.65375593,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-sa","oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jat/32/5/32_65313/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/jat/32/5/32_65313/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.5551/jat.65313","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39617479","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12055506","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12055506/pdf/jat-32-630.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12055506","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12055506?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Adipokines, Inflammation, and Metabolic Diseases","Genetic Associations and Epidemiology","Atherosclerosis and Cardiovascular Diseases","Humans","Atherosclerosis","Mendelian Randomization Analysis","Genome-Wide Association Study","Polymorphism, Single Nucleotide","Male","Risk Factors","Proteins"],"mesh_terms":["Humans","Male","Proteins","Risk Factors","Polymorphism, Single Nucleotide","Atherosclerosis","Genome-Wide Association Study","Mendelian Randomization Analysis"],"keywords":["Mendelian randomization","Multivariate statistics","Mendelian inheritance","Multivariate analysis","Causal inference","Randomization","Medicine","Genetics","Internal medicine","Genetic variants","Biology","Bioinformatics","Randomized controlled trial","Gene","Genotype","Pathology","Statistics","Mathematics","Atherosclerosis","Ischemic stroke","coronary artery disease","Multivariate","C1q/tnf-related Protein-1"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refsnp"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T12:44:52.337205Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}