{"doi":"10.5551/jat.64326","title":"Utility of the ACD-GENE-CLI Score in Asian Patients with Critical Limb Ischemia Undergoing Endovascular Interventions","abstract":null,"journal":"Journal of Atherosclerosis and Thrombosis","year":2024,"id":640224,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1663840,"name":"Po-Sen Huang","orcid":null,"position":1,"is_corresponding":false},{"id":1663841,"name":"Li-Wei Su","orcid":null,"position":2,"is_corresponding":false},{"id":1663842,"name":"Chia-Te Liao","orcid":"0000-0001-7036-9565","position":3,"is_corresponding":false},{"id":1663843,"name":"Han Siong Toh","orcid":null,"position":4,"is_corresponding":false},{"id":1559813,"name":"Yi-Chen Chen","orcid":null,"position":5,"is_corresponding":false},{"id":1663844,"name":"Chung‑Han Ho","orcid":null,"position":6,"is_corresponding":false},{"id":1663845,"name":"Zhih-Cherng Chen","orcid":null,"position":7,"is_corresponding":false},{"id":1663846,"name":"Po-Chao Hsu","orcid":null,"position":8,"is_corresponding":false},{"id":1663847,"name":"Chon-Seng Hong","orcid":null,"position":9,"is_corresponding":false},{"id":161543,"name":"Wei-Ting Chang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Utility of the ACD-GENE-CLI Score in Asian Patients with Critical Limb Ischemia Undergoing Endovascular Interventions","abstract":"AIMS: Critical limb ischemia (CLI) is an emerging public health threat and lacks a reliable score for predicting the outcomes. The Age, Body Mass Index, Chronic Kidney Disease, Diabetes, and Genotyping (ABCD-GENE) risk score helps identify patients with coronary artery disease who have cytochrome P450 2C19 (CYP2C19) polymorphism-related drug resistance and are at risk for cardiovascular adverse events. However, its application to CLI remains unknown. In this study, we aim to validate a modified ACD-GENE-CLI score to improve the prediction of major adverse limb events (MALEs) in patients with CLI receiving clopidogrel. METHODS: Patients with CLI receiving clopidogrel post-endovascular intervention were enrolled prospectively in two medical centers. Amputation and revascularization as MALEs were regarded as the outcomes. RESULTS: A total of 473 patients were recruited, with a mean follow-up duration of 25 months. Except for obesity, old age, diabetes, chronic kidney disease (CKD), and CYP2C19 polymorphisms were significantly associated with MALEs. Using bootstrap regression analysis, we established a modified risk score (ACD-GENE-CLI) that included old age (≥ 65 years), diabetes, CKD, and CYP2C19 polymorphisms. At a cutoff value of 8, the ACD-GENE-CLI score was superior to the CYP2C19 deficiency only, and the conventional ABCD-GENE score in predicting MALEs (area under the curve: 0.69 vs. 0.59 vs. 0.67, p=0.01). The diagnostic ability of the ACD-GENE-CLI score was consistent in the external validation. Also, Kaplan-Meier curves showed that in CYP2C19 deficiency, the ABCD-GENE and ACD-GENE-CLI scores could all differentiate patients with CLI who are free from MALEs. CONCLUSIONS: The modified ACD-GENE-CLI score could differentiate patients with CLI receiving clopidogrel who are at risk of MALEs. Further studies are required to generalize the utility of the score.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38092392","pmcid":"PMC11079481","openalex_id":"https://openalex.org/W4389541294","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.31753775,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc-sa","oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_64326/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_64326/_pdf","host_type":"publisher"},{"url":"https://www.jstage.jst.go.jp/article/jat/31/5/31_64326/_pdf","host_type":"publisher"},{"url":"http://dx.doi.org/10.5551/jat.64326","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38092392","host_type":"repository"},{"url":"https://ir.cnu.edu.tw//handle/310902800/34900","host_type":""},{"url":"https://lirias.kuleuven.be/handle/20.500.12942/752286","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11079481","host_type":"repository"},{"url":"https://ir.cnu.edu.tw//retrieve/70529/jat.64326.pdf","host_type":""},{"url":"https://lirias.kuleuven.be/retrieve/699e061d-3718-477b-a322-ba2c19ec9cad","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11079481/pdf/jat-31-572.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11079481","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11079481?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Peripheral Artery Disease Management","Antiplatelet Therapy and Cardiovascular Diseases","Cerebrovascular and Carotid Artery Diseases","Aged","Female","Humans","Male","Middle Aged","Asian People","Clopidogrel","Cytochrome P-450 CYP2C19","Endovascular Procedures","Follow-Up Studies","Genotype","Ischemia","Platelet Aggregation Inhibitors","Prognosis","Prospective Studies","Risk Assessment","Risk Factors"],"mesh_terms":["Clopidogrel","Aged","Female","Follow-Up Studies","Genotype","Humans","Ischemia","Male","Middle Aged","Platelet Aggregation Inhibitors","Prognosis","Prospective Studies","Risk Factors","Risk Assessment","Asian People","Endovascular Procedures","Cytochrome P-450 CYP2C19"],"keywords":["Medicine","Critical limb ischemia","Internal medicine","Diabetes mellitus","Coronary artery disease","Genotyping","Clopidogrel","Kidney disease","Adverse effect","Body mass index","Psychological intervention","Cardiology","Revascularization","Myocardial infarction","Genotype","Gene","Cyp2c19 Polymorphism","Acd-gene-cli Score"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refsnp"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T08:24:39.420702Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}