{"doi":"10.5551/jat.44396","title":"Validity of a Novel Method for Estimating Low-Density Lipoprotein Cholesterol Levels in Cardiovascular Disease Patients Treated with Statins","abstract":null,"journal":"Journal of Atherosclerosis and Thrombosis","year":2018,"id":658697,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1719518,"name":"Takuro Takumi","orcid":null,"position":1,"is_corresponding":false},{"id":700577,"name":"Masaaki Miyata","orcid":"0000-0002-7727-3432","position":2,"is_corresponding":false},{"id":1719519,"name":"Daisuke Kanda","orcid":null,"position":3,"is_corresponding":false},{"id":1719520,"name":"Ippei Kosedo","orcid":null,"position":4,"is_corresponding":false},{"id":1719521,"name":"Satoshi Yoshino","orcid":null,"position":5,"is_corresponding":false},{"id":1555420,"name":"Mitsuru Ohishi","orcid":null,"position":6,"is_corresponding":false},{"id":1719517,"name":"Takeshi Sonoda","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Validity of a Novel Method for Estimating Low-Density Lipoprotein Cholesterol Levels in Cardiovascular Disease Patients Treated with Statins","abstract":"AIM: The Friedewald equation is the standard method for estimating low-density lipoprotein cholesterol (LDL-C) levels [LDL-C(F)] and fixes the ratio of triglyceride (TG) to very LDL-C at 5. However, this has been reported to underestimate LDL-C, particularly in patients with LDL-C ＜70 mg/dL. A novel method for LDL-C estimation [LDL-C(M)] using an adjustable factor instead of a fixed value of 5 has recently been proposed. The purpose of this study was to validate LDL-C(M) in Japanese patients with cardiovascular disease (CVD) treated with statins. METHODS: In 385 consecutive CVD patients treated with statins, LDL-C(M) and LDL-C(F) levels were compared with directly measured LDL-C [LDL-C(D)]. RESULTS: Mean LDL-C(D), LDL-C(F), and LDL-C(M) were 81.7±25.5, 76.4±24.6, and 79.9±24.5 mg/dL, respectively. In all patients, both LDL-C(F) and LDL-C(M) were significantly correlated with LDL-C(D) [LDL-C(F) vs. LDL-C(D): R=0.974, p＜0.001; LDL-C(M) vs. LDL-C(D): R=0.987, p＜0.001]. In patients with LDL-C(D) ＜70 mg/dL, LDL-C(M) showed a better correlation with LDLC(D) compared with LDL-C(F) [LDL-C(M) vs. LDL-C(D): R=0.935, p＜0.001; LDL-C(F) vs. LDLC(D): R=0.868, p＜0.001]. In contrast, the correlation of LDL-C(D) with LDL-C(M) or LDL-C(F) was similar in patients with LDL-C(D) ≥70 mg/dL. CONCLUSIONS: In Japanese patients with CVD treated with statins, LDL-C level estimated by this novel method might be more accurate than those estimated using the Friedewald equation for LDL-C levels ＜70 mg/dL.","is_dataset_classified":null,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29794412","pmcid":"PMC6055036","openalex_id":"https://openalex.org/W2803832152","authors":[],"funders":[],"total_grants":0,"fwci":2.2094,"citation_percentile":0.869808,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":5},{"year":2024,"count":3}],"oa_status":"gold","license":"cc-by-nc-sa","oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jat/25/7/25_44396/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/jat/25/7/25_44396/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.5551/jat.44396","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29794412","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6055036","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6055036","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6055036?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Lipoproteins and Cardiovascular Health","Diabetes, Cardiovascular Risks, and Lipoproteins","Atherosclerosis and Cardiovascular Diseases","Aged","Algorithms","Cardiovascular Diseases","Cholesterol, LDL","Coronary Artery Disease","Female","Humans","Hydroxymethylglutaryl-CoA Reductase Inhibitors","Japan","Male","Middle Aged","Peripheral Arterial Disease","Reproducibility of Results","Retrospective Studies","Triglycerides"],"mesh_terms":["Aged","Algorithms","Cardiovascular Diseases","Coronary Artery Disease","Female","Humans","Japan","Cholesterol, LDL","Male","Middle Aged","Retrospective Studies","Triglycerides","Reproducibility of Results","Hydroxymethylglutaryl-CoA Reductase Inhibitors","Peripheral Arterial Disease"],"keywords":["Ldl cholesterol","Internal medicine","Low-density lipoprotein","Triglyceride","Medicine","Endocrinology","Cholesterol","Chemistry","Cardiovascular disease","Statin","Low-density Lipoprotein Cholesterol","Friedewald Equation","Martin Method"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T05:04:02.699622Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}