{"doi":"10.5551/jat.13.209","title":"Analysis of the Factors Contributing to Serum Retinol Binding Protein and Transthyretin Levels in Japanese Adults","abstract":null,"journal":"Journal of Atherosclerosis and Thrombosis","year":2006,"id":663330,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1731842,"name":"Yasuko Matsutani","orcid":null,"position":1,"is_corresponding":false},{"id":1731843,"name":"Yoshiko Fukuchi","orcid":null,"position":2,"is_corresponding":false},{"id":1731845,"name":"Kensuke Saito","orcid":null,"position":3,"is_corresponding":false},{"id":1731846,"name":"Michitaka Naito","orcid":null,"position":4,"is_corresponding":false},{"id":506933,"name":"Akihiro Yoshida","orcid":"0000-0002-9785-9035","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Analysis of the Factors Contributing to Serum Retinol Binding Protein and Transthyretin Levels in Japanese Adults","abstract":"OBJECTIVE: We examined various factors possibly related to metabolic syndrome, particularly focusing on nutritional assessment proteins such as retinol binding protein (RBP) and transthyretin (TTR), and remnant lipoproteins. MATERIALS AND METHODS: Fasting serum lipid was analyzed in 58 Japanese adult volunteers (33 men and 25 women, 42.5 +/- 10.1 years old). RESULTS: The lipid profiles of the subjects were classified by lipoprotein polyacrylamide gel electrophoretic patterns into Types S (n = 10), A (n = 37), and N (n = 11), according to the method described in Internal Medicine 42: 244, 2003. RBP and TTR were significantly higher in Type N than in Types S and A. In multivariate analysis, RBP was accounted for by remnant-like particle-triglyceride (RLP-TG), interleukin 6, body mass index and low-density lipoprotein (LDL)-cholesterol (adjusted R2 = 0.621). TTR was accounted for by lipoprotein(a), adiponectin and RLP-TG (adjusted R2 = 0.415). Malondialdehyde-LDL was significantly accounted for by LDL-cholesterol and RLP-cholesterol (adjusted R2 = 0.601). Lipoprotein(a) and LDL-cholesterol were independent variables for oxidized LDL antigen (adjusted R2 = 0.620). High-sensitivity C-reactive protein was accounted for by interleukin 6, immunoreactive insulin and oxidized LDL antigen (adjusted R2 = 0.361). Uric acid and body mass index were independent variables for adiponectin (adjusted R2 = 0.429). CONCLUSION: RBP and TTR may be useful as convenient and simple clinical markers of overnutrition and possibly of metabolic syndrome.","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16908954","pmcid":null,"openalex_id":"https://openalex.org/W1999046356","authors":[],"funders":[],"total_grants":0,"fwci":2.1625,"citation_percentile":0.86295688,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2014,"count":3},{"year":2015,"count":2},{"year":2018,"count":1},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2024,"count":1}],"oa_status":"hybrid","license":"cc-by-nc-sa","oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jat/13/4/13_4_209/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/jat/13/4/13_4_209/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.5551/jat.13.209","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16908954","host_type":"repository"}],"fields_of_study":["Retinoids in leukemia and cellular processes","Antioxidant Activity and Oxidative Stress","Adipokines, Inflammation, and Metabolic Diseases","Adult","C-Reactive Protein","Electrophoresis, Polyacrylamide Gel","Female","Humans","Japan","Lipoproteins","Lipoproteins, LDL","Male","Malondialdehyde","Metabolic Syndrome","Middle Aged","Multivariate Analysis","Prealbumin","Retinol-Binding Proteins"],"mesh_terms":["Adult","C-Reactive Protein","Electrophoresis, Polyacrylamide Gel","Female","Humans","Japan","Lipoproteins","Lipoproteins, LDL","Male","Malondialdehyde","Middle Aged","Prealbumin","Retinol-Binding Proteins","Multivariate Analysis","Metabolic Syndrome"],"keywords":["Transthyretin","Retinol binding protein","Retinol binding protein 4","Retinol","Medicine","Internal medicine","Endocrinology","Vitamin","Obesity"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T21:15:18.478301Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}