{"doi":"10.5483/bmbrep.2010.43.9.629","title":"Endotoxin-induced renal tolerance against ischemia and reperfusion injury is removed by iNOS, but not eNOS, gene-deletion","abstract":null,"journal":"BMB Reports","year":2010,"id":614618,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1583849,"name":"Hee-Seong Jang","orcid":null,"position":1,"is_corresponding":false},{"id":1583850,"name":"Kwon-Moo Park","orcid":null,"position":2,"is_corresponding":false},{"id":1583848,"name":"Jee-In Kim","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Endotoxin-induced renal tolerance against ischemia and reperfusion injury is removed by iNOS, but not eNOS, gene-deletion","abstract":"Endotoxin including lipopolysaccharide (LPS) confers organ tolerance against subsequent challenge by ischemia and reperfusion (I/R) insult. The mechanisms underlying this powerful adaptive defense remain to be defined. Therefore, in this study we attempted to determine whether nitric oxide (NO) and its associated enzymes, inducible NOS (iNOS) and endothelial NOS (eNOS, a constitutive NOS), are associated with LPS-induced renal tolerance against I/R injury, using iNOS (iNOS knock-out) or eNOS (eNOS knock-out) gene-deleted mice. A systemic low dose of LPS pretreatment protected kidney against I/R injury. LPS treatment increased the activity and expression of iNOS, but not eNOS, in kidney tissue. LPS pretreatment in iNOS, but not eNOS, knock-out mice did not protect kidney against I/R injury. In conclusion, the kidney tolerance to I/R injury conferred by pretreatment with LPS is mediated by increased expression and activation of iNOS.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20846496","pmcid":null,"openalex_id":"https://openalex.org/W2019650760","authors":[],"funders":[],"total_grants":0,"fwci":0.5163,"citation_percentile":0.66481481,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":4},{"year":2017,"count":2}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.5483/bmbrep.2010.43.9.629","host_type":"journal"},{"url":"https://doi.org/10.5483/bmbrep.2010.43.9.629","host_type":"publisher"},{"url":"http://ocean.kisti.re.kr/downfile/crosscheck/ksbmb/JAKO201028552429231.pdf","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20846496","host_type":"repository"}],"fields_of_study":["Nitric Oxide and Endothelin Effects","Eicosanoids and Hypertension Pharmacology","Cardiac Ischemia and Reperfusion","Animals","Blotting, Western","Kidney","Lipopolysaccharides","Male","Mice","Mice, Knockout","Nitric Oxide Synthase Type II","Nitric Oxide Synthase Type III","Reperfusion Injury"],"mesh_terms":["Animals","Kidney","Lipopolysaccharides","Male","Blotting, Western","Reperfusion Injury","Mice, Knockout","Mice","Nitric Oxide Synthase Type II","Nitric Oxide Synthase Type III"],"keywords":["Enos","Lipopolysaccharide","Nitric oxide","Kidney","Nitric oxide synthase","Endothelial NOS","Acute kidney injury","Ischemia","Reperfusion injury","Medicine","Pharmacology","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T14:46:55.801321Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}