{"doi":"10.5414/cp204502","title":"Pharmacokinetics of apixaban in patients undergoing pancreaticoduodenectomy (PAP-UP)","abstract":"OBJECTIVE: The impact of pancreaticoduodenectomy on absorption of drugs in the duodenum remains largely unknown. We aim to characterize the pharmacokinetics of apixaban in patients who had previously undergone pancreaticoduodenectomy. MATERIALS AND METHODS: ) were compared against healthy historical control subjects (N = 12). Geometric mean ratios (GMR) with 90% confidence interval (CI) were calculated for determination of comparative bioequivalence. RESULTS: between study subjects and healthy controls was 1.12 (90% CI 0.77 - 1.63). CONCLUSION: The pharmacokinetic characteristics of apixaban in subjects who had undergone pancreaticoduodenectomy are not significantly different from those of healthy controls. Though the sample size of this study is small, results suggest that no change to apixaban dose regimen is needed in patients who have had a pancreaticoduodenectomy.","journal":"International Journal of Clinical Pharmacology and Therapeutics","year":2024,"id":479996,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8977,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":533698,"name":"Edwin Lam","orcid":"0000-0001-6051-3498","position":1,"is_corresponding":false},{"id":687534,"name":"Peter J. Altshuler","orcid":"0000-0002-2993-0012","position":2,"is_corresponding":false},{"id":731175,"name":"Madison Crutcher","orcid":"0000-0002-6593-1389","position":3,"is_corresponding":false},{"id":431000,"name":"Harish Lavu","orcid":"0000-0001-8907-9242","position":4,"is_corresponding":false},{"id":68537,"name":"Charles J. Yeo","orcid":"0000-0001-8097-0071","position":5,"is_corresponding":false},{"id":761835,"name":"Douglas F. Stickle","orcid":"0000-0002-2033-4943","position":6,"is_corresponding":false},{"id":326682,"name":"Benjamin E. Leiby","orcid":"0000-0003-0761-8383","position":7,"is_corresponding":false},{"id":63814,"name":"Walter K. Kraft","orcid":"0000-0002-5074-0141","position":8,"is_corresponding":false},{"id":533700,"name":"Richard Zheng","orcid":"0000-0002-4743-5568","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T02:06:58.305365Z","pmid":"38660886","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}