{"doi":"10.5363/tits.16.4_83","title":"Design of Adaptive Behavior Seen in a Shrew Species (Suncus murinus)","abstract":null,"journal":"TRENDS IN THE SCIENCES","year":2011,"id":655587,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1711406,"name":"Keiichiro TSUJI","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Design of Adaptive Behavior Seen in a Shrew Species (Suncus murinus)","abstract":"Anti-topoisomerase I (anti-Scl-70) antibodies are strongly associated with systemic sclerosis and fibrotic organ involvement. However, their significance in ANA-positive individuals without established systemic sclerosis remains unclear. We investigated whether isolated anti-Scl-70 positivity is associated with subclinical cardiac involvement. This retrospective single-center study included 486 ANA-positive individuals identified between 2016 and 2026. Patients were classified as anti-Scl-70-positive (n = 242) or anti-Scl-70-negative (n = 244). Individuals with systemic sclerosis, other rheumatologic diseases, cardiovascular disease (except hypertension), malignancy, or advanced renal/hepatic disease were excluded. All anti-Scl-70-positive patients remained free of systemic sclerosis during at least 12 months of follow-up. Electrocardiographic Diastolic Index-1 (EDI-1) and EDI-2 were calculated from standard 12-lead ECGs. Demographic characteristics, inflammatory markers, ANA titers, and most ENA antibodies were similar between groups. Anti-Ro52 positivity was more frequent in anti-Scl-70-positive individuals (p = 0.004). EDI-1 was significantly lower, whereas EDI-2 was significantly higher in the anti-Scl-70-positive group (both p < 0.001). Among patients with available echocardiographic data, anti-Scl-70-positive individuals demonstrated higher E/e' ratios (p = 0.004) and lower LV-GLS values (p = 0.046). EDI-1 showed a strong correlation with E/e' (rs = -0.898, p < 0.001). In multivariable analysis, anti-Scl-70 positivity was the only independent predictor of electrocardiographic diastolic dysfunction (p < 0.001). Isolated anti-Scl-70 positivity is associated with impaired electrocardiographic markers of diastolic function in ANA-positive individuals without overt systemic sclerosis. These findings suggest that isolated anti-Scl-70 positivity is associated with early subclinical myocardial involvement and support further investigation of ECG-derived diastolic indices as potential screening tools in this population.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42572046","pmcid":null,"openalex_id":"https://openalex.org/W651229102","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.03734756,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/tits/16/4/16_4_4_83/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/tits/16/4/16_4_4_83/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.5363/tits.16.4_83","host_type":"journal"}],"fields_of_study":["Reproductive biology and impacts on aquatic species","Marine and fisheries research","Humans","Female","Male","Electrocardiography","Middle Aged","Retrospective Studies","Scleroderma, Systemic","Adult","Antibodies, Antinuclear","DNA Topoisomerases, Type I","Diastole","Aged","Biomarkers"],"mesh_terms":["Humans","Female","Male","Electrocardiography","Middle Aged","Retrospective Studies","Scleroderma, Systemic","Adult","Antibodies, Antinuclear","DNA Topoisomerases, Type I","Diastole","Aged","Biomarkers"],"keywords":["Suncus","Shrew","Zoology","Biology","Anti-Scl-70","Diastolic dysfunction","Electrocardiographic diastolic index","Systemic sclerosis"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T18:08:15.974678Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}