{"doi":"10.53519/analesranf.2022.88.05.07","title":"Neuraminidase / sialidase from influenza virus: its characteristics, nomenclature, measuring of activity, kinetics, inhibitors as therapeutic agents","abstract":"<jats:p>The main characteristics of neuraminidase / sialidase from Influenza Virus and its peculiar nomenclature are described, as well as two new, sensitive and simple procedures (fluorometric and by luminiscence) for measuring neuraminidase activity, which have been used at the Department of Biochemistry and Molecular Biology of the University of Salamanca (Prof. J. A. Cabezas). The kinetics of neuraminidase of three A and three B Influenza Virus Strains, and the result of the comparison of biological and physical properties of human and animal origin (pig and duck) Virus Strains, belonging to the same subtype A(H1N1), are described. Finally, the advantages and risks for the use as therapeutic agents against Influenza of the Influenza Virus neuraminidase inhibitors Zanamivir, Oseltamivir and Peramivir are discussed.\n\nKeywords: neuraminidase / sialidase; influenza virus; inhibitors</jats:p>","journal":"Anales de la Real Academia Nacional de Farmacia","year":2022,"id":644540,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1677715,"name":"José Antonio Cabezas Fernández del Campo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Neuraminidase / sialidase from influenza virus: its characteristics, nomenclature, measuring of activity, kinetics, inhibitors as therapeutic agents","abstract":"<jats:p>The main characteristics of neuraminidase / sialidase from Influenza Virus and its peculiar nomenclature are described, as well as two new, sensitive and simple procedures (fluorometric and by luminiscence) for measuring neuraminidase activity, which have been used at the Department of Biochemistry and Molecular Biology of the University of Salamanca (Prof. J. A. Cabezas). The kinetics of neuraminidase of three A and three B Influenza Virus Strains, and the result of the comparison of biological and physical properties of human and animal origin (pig and duck) Virus Strains, belonging to the same subtype A(H1N1), are described. Finally, the advantages and risks for the use as therapeutic agents against Influenza of the Influenza Virus neuraminidase inhibitors Zanamivir, Oseltamivir and Peramivir are discussed.\n\nKeywords: neuraminidase / sialidase; influenza virus; inhibitors</jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19910364","pmcid":null,"openalex_id":"https://openalex.org/W4385154596","authors":[],"funders":[],"total_grants":0,"fwci":0.154,"citation_percentile":0.54427421,"influential_citations":0,"citation_trend":[{"year":2022,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://analesranf.com//wp-content/uploads/2022/88_ex/88ex_07.pdf","host_type":"journal"},{"url":"https://analesranf.com//wp-content/uploads/2022/88_ex/88ex_07.pdf","host_type":"publisher"},{"url":"https://doi.org/10.53519/analesranf.2022.88.05.07","host_type":"journal"}],"fields_of_study":["Influenza Virus Research Studies","Respiratory viral infections research","vaccines and immunoinformatics approaches"],"mesh_terms":[],"keywords":["Neuraminidase","Zanamivir","Sialidase","Virology","Virus","Neuraminidase inhibitor","Oseltamivir","Influenza A virus","Orthomyxoviridae","Biology","Microbiology","Chemistry","Medicine","Coronavirus disease 2019 (COVID-19)","Pathology","Infectious disease (medical specialty)"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:23:41.717979Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}