{"doi":"10.5306/wjco.v16.i2.100807","title":"Current and future perspectives in the management and treatment of colorectal cancer","abstract":"<jats:p>In this editorial, we reviewed the article by Fadlallah et al  that was recently published in the World Journal of Clinical Oncology . The article provided a comprehensive and in-depth view of the management and treatment of colorectal cancer (CRC), one of the leading causes of cancer-related morbidity and mortality worldwide. The article analyzed the therapeutic modalities and their sequencing, focusing on total neoadjuvant therapy for locally advanced rectal cancer. It highlighted the role of immunotherapy in tumors with high microsatellite instability or deficient mismatch repair, addressing recent advances that have improved prognosis and therapeutic response in localized and metastatic CRC. Innovations in surgical techniques, advanced radiotherapy, and systemic agents targeting specific mutational profiles are also discussed, reflecting on how they revolutionized clinical management. Circulating tumor DNA has emerged as a promising tool for detecting minimal residual disease, prognosis, and therapeutic monitoring, solidifying its role in precision oncology. This review emphasized the importance of technological and therapeutic advancements in improving clinical outcomes and personalizing CRC treatment.</jats:p>","journal":"World Journal of Clinical Oncology","year":2025,"id":597422,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1530553,"name":"Evita Krumina","orcid":null,"position":1,"is_corresponding":false},{"id":1530554,"name":"Fernando López-Campos","orcid":null,"position":2,"is_corresponding":false},{"id":1530555,"name":"Felipe Couñago","orcid":null,"position":3,"is_corresponding":false},{"id":1530552,"name":"Sigfredo E Romero-Zoghbi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Current and future perspectives in the management and treatment of colorectal cancer","abstract":"<jats:p>In this editorial, we reviewed the article by Fadlallah et al  that was recently published in the World Journal of Clinical Oncology . The article provided a comprehensive and in-depth view of the management and treatment of colorectal cancer (CRC), one of the leading causes of cancer-related morbidity and mortality worldwide. The article analyzed the therapeutic modalities and their sequencing, focusing on total neoadjuvant therapy for locally advanced rectal cancer. It highlighted the role of immunotherapy in tumors with high microsatellite instability or deficient mismatch repair, addressing recent advances that have improved prognosis and therapeutic response in localized and metastatic CRC. Innovations in surgical techniques, advanced radiotherapy, and systemic agents targeting specific mutational profiles are also discussed, reflecting on how they revolutionized clinical management. Circulating tumor DNA has emerged as a promising tool for detecting minimal residual disease, prognosis, and therapeutic monitoring, solidifying its role in precision oncology. This review emphasized the importance of technological and therapeutic advancements in improving clinical outcomes and personalizing CRC treatment.</jats:p>","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39995555","pmcid":"PMC11686563","openalex_id":"https://openalex.org/W4405231509","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.5306/wjco.v16.i2.100807","host_type":"journal"},{"url":"https://doi.org/10.5306/wjco.v16.i2.100807","host_type":"publisher"},{"url":"https://www.wjgnet.com/2218-4333/full/v16/i2/100807.htm","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39995555","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11686563","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11686563","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11686563?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Colorectal Cancer Surgical Treatments","Colorectal Cancer Treatments and Studies","Colorectal Cancer Screening and Detection"],"mesh_terms":[],"keywords":["Medicine","Colorectal cancer","Intensive care medicine","Cancer treatment","Current (fluid)","General surgery","Cancer","Oncology","Internal medicine","Immunotherapy","Chemotherapy","Chemoradiotherapy","Metastatic Colorectal Cancer","Colon Surgery","Rectal Surgery","Total Neoadjuvant Therapy"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T13:12:21.519254Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}