{"doi":"10.5301/ejo.2011.6324","title":"Efficacy of 3 Different Artificial Tears for the Treatment of Dry Eye in Frequent Computer Users and/or Contact Lens Users","abstract":"<jats:sec>\n                    <jats:title>Purpose</jats:title>\n                    <jats:p>To compare the efficacy of 3 different artificial tears (AT) acting primarily in one of the 3 tear film layers (Tears Again®, lipidic; Opticol®, aqueous; Optive®, mucin) in recovering the tear film changes in patients with dry eye symptoms due to external causes.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>A total of 27 patients, with dry eye symptoms associated with extra hours of computer or contact lenses use, were randomized to 4 treatment groups: A received Tears Again®; B received Optive®; C received Opticol®; D received no treatment (control). Patients were observed in 3 visits: day 0, day 7, and day 30. Tear break-up time (TBUT) and Schirmer tests and the Ocular Surface Disease Index were performed. Data analysis was performed.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>There were no significant differences between the groups. From day 0 to day 30, there was a decrease in the number of eyes with abnormal TBUT (not significant) and Schirmer (significant in A, B, D; p&lt;0.031). There was an increase in the average TBUT for all groups (significant in A, C; p&lt;0.001) and a decrease in the average Schirmer value in groups B, C, and D (not significant) and an increase in group A (p=0.002). There was a decrease in the average Ocular Surface Disease Index value in all groups (p&lt;0.045).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions</jats:title>\n                    <jats:p>All AT were efficient at recovering the tear film, but those acting primarily on the internal and intermediate layer led to a mild decline on lachrymal production. An association of different kinds of AT acting on each layer can be the best treatment for corneal surface diseases affecting eye lubrication.</jats:p>\n                  </jats:sec>","journal":"European Journal of Ophthalmology","year":2011,"id":686531,"datarank":0.5244761342199721,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.0,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1793583,"name":"Cristina Borges","orcid":null,"position":1,"is_corresponding":false},{"id":1793585,"name":"Sandrina Nunes","orcid":null,"position":2,"is_corresponding":false},{"id":1793587,"name":"José Salgado-Borges","orcid":null,"position":3,"is_corresponding":false},{"id":1793588,"name":"Lilianne Duarte","orcid":null,"position":4,"is_corresponding":false},{"id":1793581,"name":"Gil Calvão-Santos","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Efficacy of 3 Different Artificial Tears for the Treatment of Dry Eye in Frequent Computer Users and/or Contact Lens Users","abstract":"<jats:sec>\n                    <jats:title>Purpose</jats:title>\n                    <jats:p>To compare the efficacy of 3 different artificial tears (AT) acting primarily in one of the 3 tear film layers (Tears Again®, lipidic; Opticol®, aqueous; Optive®, mucin) in recovering the tear film changes in patients with dry eye symptoms due to external causes.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>A total of 27 patients, with dry eye symptoms associated with extra hours of computer or contact lenses use, were randomized to 4 treatment groups: A received Tears Again®; B received Optive®; C received Opticol®; D received no treatment (control). Patients were observed in 3 visits: day 0, day 7, and day 30. Tear break-up time (TBUT) and Schirmer tests and the Ocular Surface Disease Index were performed. Data analysis was performed.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>There were no significant differences between the groups. From day 0 to day 30, there was a decrease in the number of eyes with abnormal TBUT (not significant) and Schirmer (significant in A, B, D; p&lt;0.031). There was an increase in the average TBUT for all groups (significant in A, C; p&lt;0.001) and a decrease in the average Schirmer value in groups B, C, and D (not significant) and an increase in group A (p=0.002). There was a decrease in the average Ocular Surface Disease Index value in all groups (p&lt;0.045).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions</jats:title>\n                    <jats:p>All AT were efficient at recovering the tear film, but those acting primarily on the internal and intermediate layer led to a mild decline on lachrymal production. An association of different kinds of AT acting on each layer can be the best treatment for corneal surface diseases affecting eye lubrication.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21298628","pmcid":null,"openalex_id":"https://openalex.org/W2092842778","authors":[],"funders":[],"total_grants":0,"fwci":1.905,"citation_percentile":0.86143099,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":2},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":4},{"year":2022,"count":4},{"year":2023,"count":2},{"year":2024,"count":4},{"year":2025,"count":1}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.5301/EJO.2011.6324","host_type":"publisher"},{"url":"https://doi.org/10.5301/ejo.2011.6324","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21298628","host_type":"repository"}],"fields_of_study":["Ocular Surface and Contact Lens","Corneal Surgery and Treatments","Ocular Infections and Treatments","Adult","Computer Systems","Contact Lenses","Dry Eye Syndromes","Female","Humans","Male","Middle Aged","Occupational Diseases","Ophthalmic Solutions","Surveys and Questionnaires","Tears","Treatment Outcome","Young Adult"],"mesh_terms":["Adult","Computer Systems","Contact Lenses","Female","Humans","Male","Middle Aged","Occupational Diseases","Ophthalmic Solutions","Surveys and Questionnaires","Tears","Dry Eye Syndromes","Treatment Outcome","Young Adult"],"keywords":["Tears","Artificial tears","Medicine","Contact lens","Ophthalmology","Schirmer test","Dry eyes","Surgery"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T19:45:36.110711Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}