{"doi":"10.5282/edoc.27942","title":"Regulation of the central apoptotic pathway during C. elegans development","abstract":"have a potential impact on key integrator of apoptotic stimuli, egl-1.The analysis is based on the C. elegans gene ontology and expression data available for defined stages during embryonic development.For prediction of the potential impact, I compare normalized expression patterns of candidates to the expression of egl-1 which starts peaking close to the first wave of cell death.Gene ontology data is extracted via an API of the wormmine database and is subsequently processed within a self-developed Python application. The central cell death pathway in Caenorhabditis elegansGenetically these 131 developmental cell deaths are induced by the central cell death pathway, which is comprised of four members.EGL-1 (egg laying defective) and CED-9, CED-4 and CED-3 (cell death abnormal).Loss of function (lf) mutations in either EGL-1 (Conradt and Horvitz, 1998), CED-3 or CED-4 lead to survival of nearly all 131 cells, which normally die during embryonic development; these genes therefore have a pro-apoptotic function (Ellis and Horvitz, 1986).In CED-9 gain-of-function (gf) mutants, apoptosis is blocked and contrary CED-9(lf) mutants show excessive cell death, resulting in an anti-apoptotic function of CED-9 (Hengartner et al., 1992).Epistasis studies have revealed that the pathway is triggered by the most upstream factor, EGL-1 in Caenorhabditis elegans',","journal":"Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)","year":2021,"id":225695,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6035,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":828835,"name":"Sebastian Lühr","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:54:30.292454Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}