{"doi":"10.5281/zenodo.4001718","title":"The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy","abstract":"Human organoids – three-dimensional structures of cells that recapitulate important aspects of organ development in vitro – hold tremendous potential for biomedical applications. To help deliver on the promises of combining human organoids with single-cell technology, we have launched an Organoid Cell Atlas pilot project, as a ‘Biological Network’ within the Human Cell Atlas (HCA), focusing on single-cell profiling of organoids and in vitro cell models (https://www.humancellatlas.org/coordinators/). The Organoid Cell Atlas will foster the production, quality control, dissemination, and utilization of single-cell and spatial genomics data for human organoids, and it will connect such datasets with the comprehensive profiles of primary tissue that are being generated within the HCA. A first step toward establishing the Organoid Cell Atlas has recently been funded by the European Union Horizon 2020 call for “Pilot actions to build the foundations of a human cell atlas” through the “HCA|Organoid” project (http://hca-organoid.eu/). This preprint outlines the rationale for combining human organoids with single-cell technology and the concrete plans for established the Organoid Cell Atlas as a Rosetta Stone for biomedical discovery and regenerative therapy.","journal":"Zenodo (CERN European Organization for Nuclear Research)","year":2020,"id":7685,"datarank":0.33129509033670657,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.12335093616872296,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.12335093616872296,"corpus_percentile":47.97710218921637,"corpus_rank":6726,"citation_count":3,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.845,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":1,"downloads":1679,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":570,"name":"Michael Boutros","orcid":"0000-0002-9458-817X","position":1,"is_corresponding":false},{"id":29631,"name":"J. Gray Camp","orcid":"0000-0003-3295-1225","position":2,"is_corresponding":false},{"id":3646,"name":"Hans Clevers","orcid":"0000-0002-3077-5582","position":4,"is_corresponding":false},{"id":29632,"name":"Juergen A. Knoblich","orcid":"0000-0002-6751-3404","position":5,"is_corresponding":false},{"id":29633,"name":"Prisca Liberali","orcid":"0000-0003-0695-6081","position":6,"is_corresponding":false},{"id":3589,"name":"Oliver Stegle","orcid":"0000-0002-8818-7193","position":9,"is_corresponding":false},{"id":29635,"name":"Hendrik G. Stunnenberg","orcid":"0000-0002-0066-1576","position":10,"is_corresponding":false},{"id":3586,"name":"Sarah A. Teichmann","orcid":"0000-0002-6294-6366","position":11,"is_corresponding":false},{"id":29636,"name":"Barbara Treutlein","orcid":"0000-0002-3299-5597","position":12,"is_corresponding":false},{"id":66010,"name":"Robert G. Vries","orcid":null,"position":13,"is_corresponding":false}],"reference_count":0,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":"green","license":"cc-by","views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}