{"doi":"10.5281/zenodo.3988139","title":"Anticovidian v.2 COVID-19: Hypothesis of the Lab Origin Versus a Zoonotic Event which can also be of a Lab Origin","abstract":"<strong>Abstract</strong>: To treat the cause of a disease and not only its effects is of the utmost importance; hence, we need to know the origin of this pandemic of COVID-19, in order to be able, if possible, to prevent an event of such a nature and magnitude in the future, and to be able to avoid every sort of abuses to humanity, as it is happening right now. Bullet points here addressed are: <strong>1</strong>) To have, inside the backbone of a virus from a bat (mostly ~97.55% of the viral RNA (by deducting the HIV inserts found by Perez, Montagnier and others), &amp; as per the findings of Petrovsky, see below, and also to contrast the differences), the insertion similar to that of a pangolin virus for the Receptor Binding Domain (RBD, which basically consists of six separated key amino acids, or the 0.06% of its genome for these particular 18 nucleotides), being their receptor the ACE2 of the human lung, appearing at a time (as earlier as since September of 2019), were there were already mature all of the molecular methodologies necessary to modify individual nucleotides (Crispr-Cas9, “Seamless”, etc.) that then modify at will the resulting amino acids, with the possibility to give an extra passage to the virus through ferrets (or other lab animals) that have an ACE2 very similar to the humans, to give it then a more “natural” appearance (by random trivial changes); because, had it been natural, this could had required an animal host infected with these two viruses simultaneously, and that with an unexplainable marksmanship, to specifically modify the key six codons (and a second independent of such impossible recombinants, to give raise to the differences exclusively present at the end of the long Orf1ab, into the Nsf15 and Nsf16); <strong>2</strong>) To have an even more important and unique peculiar site, <strong>PRRA</strong>R (encompassing the needed 12 bases to complete that sequence, being this the 0.04% of the full genome), for protease cleavage (new to Plasmin and Furin, plus Trypsin, TMRPSS2, etc.) inside the protein called Spike (S), to obtain the fragments S1 and S2 in order to allow the viral RNA to penetrate into the cell (expanding the range, not only to lung cells as the previous modification, but also to white and to neural cells), whose nucleotides producing it are highly strange to the rest of the viral sequence, because they contain more than an 83% of richness in its nucleotides GC, being these 12 nucleotides alien to the rest of the virus: CCUCGGCGGGCA (similar to bacterial and to methodological sequences patented by <em>Moderna, Inc.</em>, cleavable by restriction enzymes BsaJI, AciI, Cac8I, MnlI…), that are engrained to the three remaining bases: CGU present in the frame of the bat virus to complete the necessary sequence. This will require, either a third virus completely unknown until now, either in the same utopian animal described before, or through a second passage of the first chimera into another animal, and then that such viral beast, could also be able to target exclusively this region, and no other site whatsoever; then, it is explored, <strong>3</strong>) The biggest shot in variation, when it is compared to the first sequence obtained of the virus of COVID-19, with its immediate ancestor, that according to Shi Zheng-Li is the RaTG13 (submitted <em>a posteriori</em> of the COVID-19 first sequence, and which researchers demonstrate that this is a partially made-up sequence (see below), having her deliberately ignored even to cite her previous identical reference called BtCoV/4991 (2016), or even her most recent reference of the same that she put under the name of SARSr-CoV Ra4991 (2019), being very dishonest for her to change in at least three identified times the names of her same sequence, actions that render her highly suspicious, because she hid the rest of the sequence at least during the last four year (having been obtained from excrement in a cave, she says, after a call due to a ","journal":"Zenodo (CERN European Organization for Nuclear Research)","year":2020,"id":74782,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9647,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":390880,"name":"Fernando Castro-Chávez","orcid":"0000-0001-9661-5672","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T21:46:11.663457Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}