{"doi":"10.5281/zenodo.19078939","title":"Summary Data from \"Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects\"","abstract":"Variant in situ Sequencing (VIS-seq) is a platform for optically profiling thousands of transgenically expressed protein-coding variants simultaneously. VIS-seq comprises a cassette with a promoter expressing a circular RNA containing one or more barcodes that are sequenced in situ to reveal the identity of the variant expressed in each cell and a second promoter expressing the protein variant. We used VIS-seq to create morphological profiles comprising a large set of measurements of the intensity, distribution and shape of different markers for >3,000 variants of lamin A and PTEN from ~11.4 million cell images. Lamin A variants were expressed in U2OS cells and PTEN variants in either iPS cells or derived neurons. VIS-seq variant profiles may be explored at visseq.gs.washington.edu.","journal":"Zenodo (CERN European Organization for Nuclear Research)","year":2025,"id":587973,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10062,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.634,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1504295,"name":"Douglas Fowler","orcid":null,"position":1,"is_corresponding":false},{"id":12453,"name":"Sriram Pendyala","orcid":"0000-0003-3395-3417","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:59:43.096742Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}