{"doi":"10.52601/bpr.2021.200047","title":"Probing lysosomal activity &lt;i&gt;in vivo&lt;/i&gt;","abstract":"Lysosomes are membrane-bound organelles for biomolecule degradation and recycling. They also serve as a nutrient sensing and signaling center to maintain cell and tissue homeostasis. Lysosomal properties alter in response to developmental or environmental cues, but these changes are hard to track <i>in vivo</i>. Employing <i>C. elegans</i> as a model system, we have developed assays to examine and quantify lysosome properties <i>in vivo</i>, including lysosome maturation, acidification and cleavage activity. These assays can be used to reveal alterations of lysosomal activity during <i>C. elegans</i> development and in stress conditions.","journal":"Biophysics Reports","year":2021,"id":211788,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":802226,"name":"Sun Yanan","orcid":null,"position":1,"is_corresponding":false},{"id":802227,"name":"Wang Xiaochen","orcid":null,"position":2,"is_corresponding":false},{"id":801787,"name":"Xin Li","orcid":"0000-0002-8779-125X","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-18T23:52:23.670339Z","pmid":"37288085","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}