{"doi":"10.5152/eajm.2012.23","title":"Comparison of Esmolol to Nitroglycerine in Controlling Hypotension during Nasal Surgery","abstract":"<jats:p>Abstract\n\t \n\n\tObjective: The aim of this study was to compare esmolol to nitroglycerine in terms of effectiveness in controlling hypotension during nasal surgery. \n\n\tMaterials and Methods: After approval by our institutional Ethics Committee, 40 patients were recruited and randomized into two drug groups: esmolol (Group E) and nitroglycerine (Group N). In group E, a bolus dose of 500 μg/kg esmolol was administered over 30 sec followed by continuous administration at a dose of 25-300 μg/kg/min to maintain systolic arterial pressure at 80 mmHg. In group N, nitroglycerine was administered at a dose of 0.5-2 μg/kg/min. \n\n\tResults: During the hypotensive period, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, and heart rate were decreased 24%, 33%, 27% and 35%, respectively, in group E (p&lt;0.001, p&lt;0.001, p&lt;0.001, p&lt;0.001) and were decreased 30%, 33%, 34% and 23%, respectively, in group N (p&lt;0.001, p&lt;0.001, p&lt;0.001, p&lt;0.001). The decrease in heart rate was higher in group E during the hypotensive period (p=0.048). During the recovery period, diastolic arterial pressure and heart rate were decreased 9% and 18%, respectively, in group E (p=0.044, p&lt;0.001). Systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure were decreased 7%, 3% and 7%, respectively, in group N (p=0.049, p=0.451, p=0.045). \n\n\tConclusion: Esmolol provides hemodynamic stability and good surgical field visibility and should be considered as an alternative to nitroglycerine.</jats:p>","journal":"The Eurasian Journal of Medicine","year":2019,"id":662182,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1728671,"name":"Fatma Nur Kaya","orcid":null,"position":1,"is_corresponding":false},{"id":1728672,"name":"Belgin Yavascaoglu","orcid":null,"position":2,"is_corresponding":false},{"id":1728673,"name":"Alp Gurbet","orcid":null,"position":3,"is_corresponding":false},{"id":1728674,"name":"Nazan Has Selmi","orcid":null,"position":4,"is_corresponding":false},{"id":1728675,"name":"Sener Kaya","orcid":null,"position":5,"is_corresponding":false},{"id":1728676,"name":"Oya Kutlay","orcid":null,"position":6,"is_corresponding":false},{"id":1728670,"name":"Ayla Guney","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison of Esmolol to Nitroglycerine in Controlling Hypotension during Nasal Surgery","abstract":"<jats:p>Abstract\n\t \n\n\tObjective: The aim of this study was to compare esmolol to nitroglycerine in terms of effectiveness in controlling hypotension during nasal surgery. \n\n\tMaterials and Methods: After approval by our institutional Ethics Committee, 40 patients were recruited and randomized into two drug groups: esmolol (Group E) and nitroglycerine (Group N). In group E, a bolus dose of 500 μg/kg esmolol was administered over 30 sec followed by continuous administration at a dose of 25-300 μg/kg/min to maintain systolic arterial pressure at 80 mmHg. In group N, nitroglycerine was administered at a dose of 0.5-2 μg/kg/min. \n\n\tResults: During the hypotensive period, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, and heart rate were decreased 24%, 33%, 27% and 35%, respectively, in group E (p&lt;0.001, p&lt;0.001, p&lt;0.001, p&lt;0.001) and were decreased 30%, 33%, 34% and 23%, respectively, in group N (p&lt;0.001, p&lt;0.001, p&lt;0.001, p&lt;0.001). The decrease in heart rate was higher in group E during the hypotensive period (p=0.048). During the recovery period, diastolic arterial pressure and heart rate were decreased 9% and 18%, respectively, in group E (p=0.044, p&lt;0.001). Systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure were decreased 7%, 3% and 7%, respectively, in group N (p=0.049, p=0.451, p=0.045). \n\n\tConclusion: Esmolol provides hemodynamic stability and good surgical field visibility and should be considered as an alternative to nitroglycerine.</jats:p>","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25610218","pmcid":"PMC4261293","openalex_id":"https://openalex.org/W2145171157","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.14775194,"influential_citations":0,"citation_trend":[{"year":2016,"count":3},{"year":2017,"count":4},{"year":2018,"count":1},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":3},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2026,"count":2}],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://www.eajm.org/en/comparison-of-esmolol-to-nitroglycerine-in-controlling-hypotension-during-nasal-surgery-1616597","host_type":"journal"},{"url":"https://www.eajm.org/en/comparison-of-esmolol-to-nitroglycerine-in-controlling-hypotension-during-nasal-surgery-1616597","host_type":"publisher"},{"url":"https://eajm.org/index.php/pub/article/download/2466/2463","host_type":"publisher"},{"url":"https://doi.org/10.5152/eajm.2012.23","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25610218","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4261293","host_type":"repository"},{"url":"https://avesis.uludag.edu.tr/publication/details/6d9adcf6-bf4f-4c92-bb46-b6b6541cdad7/oai","host_type":"repository"}],"fields_of_study":["Anesthesia and Sedative Agents","Anesthesia and Pain Management","Hemodynamic Monitoring and Therapy"],"mesh_terms":[],"keywords":["Esmolol","Medicine","Blood pressure","Heart rate","Mean arterial pressure","Anesthesia","Bolus (digestion)","Diastole","Hemodynamics","Cardiology","Internal medicine","Nitroglycerin","Controlled hypotension","Esmolol Hydrochloride"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T13:04:45.196769Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}