{"doi":"10.5114/jcb.2024.140760","title":"Dose-effect relationship in external beam radiotherapy combined with brachytherapy for cervical cancer: A systematic review","abstract":null,"journal":"Journal of Contemporary Brachytherapy","year":2024,"id":630676,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1633960,"name":"Mingwei Bu","orcid":null,"position":1,"is_corresponding":false},{"id":1613638,"name":"Hairong Jiang","orcid":null,"position":2,"is_corresponding":false},{"id":356897,"name":"Xin Mu","orcid":"0000-0002-8628-490X","position":3,"is_corresponding":false},{"id":1633961,"name":"Hongfu Zhao","orcid":null,"position":4,"is_corresponding":false},{"id":307004,"name":"Ning Wu","orcid":"0000-0002-2167-3621","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dose-effect relationship in external beam radiotherapy combined with brachytherapy for cervical cancer: A systematic review","abstract":"Purpose: External beam radiotherapy with concurrent chemotherapy combined with brachytherapy has been described as the first treatment choice for locally advanced cervical cancer. This study aimed to systematically review the dose-effect relationship (DER) of target volumes and organs at risk (OARs) in external beam radiotherapy combined with brachytherapy for cervical cancer. Material and methods: Studies reporting DER in radical radiotherapy for cervical cancer were determined by searching PubMed, Web of Science, and Cochrane Library databases till Jan 20, 2023. Dose parameters of DER, end-point of tumor control or type and grade of side effects of OARs as well as prediction results were analyzed from included studies. Coordinates of DER curves from the included studies were extracted and DER curves were reconstructed in the same coordinate system for comparison. Results: of rectum versus rectal grade 2-4 side effects for dose-toxicity relationship. Conclusions: In the radical radiotherapy of cervical cancer, there were significant DERs for target volumes and OARs. Considering the interference of these factors, DERs in sub-group patients would provide precise and individualized dose constraints of radiotherapy for cervical cancer in the future.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39629086","pmcid":"PMC11609865","openalex_id":"https://openalex.org/W4400012979","authors":[],"funders":[],"total_grants":0,"fwci":0.6717,"citation_percentile":0.57559958,"influential_citations":0,"citation_trend":[{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-sa","oa_locations":[{"url":"https://www.termedia.pl/Journal/-54/pdf-54298-10?filename=Dose-effect relationship (1).pdf","host_type":"journal"},{"url":"https://www.termedia.pl/Journal/-54/pdf-54298-10?filename=Dose-effect relationship (1).pdf","host_type":"publisher"},{"url":"https://www.termedia.pl/doi_ft/10.5114/jcb.2024.140760","host_type":"publisher"},{"url":"https://doi.org/10.5114/jcb.2024.140760","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39629086","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11609865","host_type":"repository"},{"url":"https://doaj.org/article/f2f9b4c43f7944199466e6eb3307114f","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11609865/pdf/JCB-16-54298.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11609865","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11609865?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Endometrial and Cervical Cancer Treatments","Advanced Radiotherapy Techniques","Radiation Therapy and Dosimetry"],"mesh_terms":[],"keywords":["Brachytherapy","External beam radiotherapy","Cervical cancer","Medicine","Radiation therapy","Nuclear medicine","Medical physics","Cancer","Radiology","Internal medicine","dose-effect relationship"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T21:54:41.003415Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}