{"doi":"10.5114/aoms.2018.79004","title":"The function and clinical relevance of lncRNA UBE2CP3-001 in human gliomas","abstract":null,"journal":"Archives of Medical Science","year":2018,"id":668024,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1744451,"name":"Junchen Pan","orcid":null,"position":1,"is_corresponding":false},{"id":954116,"name":"Yi Ding","orcid":"0000-0002-4125-3552","position":2,"is_corresponding":false},{"id":1744452,"name":"Yan-Song Zhang","orcid":null,"position":3,"is_corresponding":false},{"id":1522347,"name":"Yanjun Zeng","orcid":null,"position":4,"is_corresponding":false},{"id":1744450,"name":"Zhengxiang Luo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The function and clinical relevance of lncRNA UBE2CP3-001 in human gliomas","abstract":"Introduction: Gliomas are the most frequent primary tumors in the human brain. Recent studies have identified a class of long noncoding RNAs, named lncRNAs, which were reported to participate in regulating the development of various diseases, including gliomas. In our previous studies, we found that lncRNA UBE2CP3-001 was overexpressed in gliomas but not in normal tissue. However, the molecular functions of UBE2CP3-001 in glioma are largely unknown. Material and methods: The presence of UBE2CP3-001 in U87 cells, glioma tissues and normal brain tissues was detected by real-time RT-PCR. The ability of U87 cells to migrate was analyzed using a cellular wound healing assay after downregulation of UBE2CP3-001. The survival rate of U87 cells after UBE2CP3-001 knockdown was also analyzed using the CCK8 assay. In vivo tumor weights from xenograft tumors transfected with UBE2CP3-001 shRNA were further analyzed using in vivo animal experiments. The expression levels of MMP-9 and TRAF3IP2 were determined by Western blot. Results: Our data showed that UBE2CP3-001 was overexpressed in most glioma tissues (p < 0.01). Downregulation of UBE2CP3-001 could inhibit cell migration (p < 0.01) and invasiveness (p < 0.01) of U87 cells. Downregulation of UBE2CP3-001 in U87 cells also suppressed the cell proliferation (p < 0.01) and promoted apoptosis (p < 0.01). Furthermore, in vivo studies confirmed that knockdown of UBE2CP3-001 could retard the growth of U87 xenograft tumors (p < 0.01). Western blot analysis showed that knockdown of UBE2CP3-001 could effectively inhibit the expression of MMP-9 (p < 0.01) and TRAF3IP2 (p < 0.01) in U87 glioma cells. Conclusions: These data suggest an important role of UBE2CP3-001 in glioma and indicate its potential application in anti-glioma therapy.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30393485","pmcid":"PMC6209712","openalex_id":"https://openalex.org/W2898598696","authors":[],"funders":[],"total_grants":0,"fwci":0.8888,"citation_percentile":0.68133743,"influential_citations":0,"citation_trend":[{"year":2019,"count":7},{"year":2020,"count":5},{"year":2021,"count":1},{"year":2022,"count":1}],"oa_status":"gold","license":"cc-by-nc-sa","oa_locations":[{"url":"https://www.termedia.pl/Journal/-19/pdf-33993-10?filename=the function.pdf","host_type":"journal"},{"url":"https://www.termedia.pl/Journal/-19/pdf-33993-10?filename=the function.pdf","host_type":"publisher"},{"url":"https://www.termedia.pl/doi_ft/10.5114/aoms.2018.79004","host_type":"publisher"},{"url":"https://doi.org/10.5114/aoms.2018.79004","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30393485","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6209712","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6209712","host_type":"repository"},{"url":"https://doaj.org/article/399d9860aa22453088663de9c3e46f15","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6209712","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6209712?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cancer-related molecular mechanisms research","Circular RNAs in diseases","Cancer Mechanisms and Therapy"],"mesh_terms":[],"keywords":["Gene knockdown","Downregulation and upregulation","Glioma","Western blot","U87","In vivo","Medicine","Cancer research","Apoptosis","Small hairpin RNA","Cell growth","Transfection","Blot","Cell","Cell culture","Biology","Gene","Proliferation","Traf3ip2","Lncrna Ube2cp3-001"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T19:50:23.738040Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}