{"doi":"10.5009/gnl210118","title":"Long-term Disease Course of Crohn’s Disease: Changes in Disease Location, Phenotype, Activities, and Predictive Factors","abstract":null,"journal":"Gut and Liver","year":2022,"id":609531,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1566726,"name":"Myung-Won You","orcid":"0000-0001-6262-5784","position":1,"is_corresponding":false},{"id":1566728,"name":"Chi Hyuk Oh","orcid":"0000-0002-4382-5876","position":2,"is_corresponding":false},{"id":1566729,"name":"Chang Kyun Lee","orcid":"0000-0002-4279-3825","position":3,"is_corresponding":false},{"id":1566731,"name":"Sung Kyoung Moon","orcid":"0000-0003-4831-3439","position":4,"is_corresponding":false},{"id":1566724,"name":"Choong Wui Cho","orcid":"0000-0003-3181-6486","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Long-term Disease Course of Crohn’s Disease: Changes in Disease Location, Phenotype, Activities, and Predictive Factors","abstract":"Crohn's disease (CD) is a chronic destructive inflammatory bowel disease that affects young people and is associated with significant morbidity. The clinical spectrum and disease course of CD are heterogeneous and often difficult to predict based on the initial presentation. In this article, changes in the disease location, behavior, clinical course during long-term follow-up, and predictive factors are reviewed. Generally, four different patterns of clinical course are discussed: remission, stable disease, chronic relapsing disease, and chronic refractory disease. Understanding the long-term disease course of CD is mandatory to reveal the underlying pathophysiology of the disease and to move toward a more optimistic disease course, such as remission or stability, and less adverse outcomes or devastating sequelae.","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34456186","pmcid":"PMC8924800","openalex_id":"https://openalex.org/W3197267427","authors":[],"funders":[],"total_grants":0,"fwci":2.8776,"citation_percentile":0.91789356,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":9},{"year":2024,"count":9},{"year":2025,"count":14},{"year":2026,"count":9}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://www.gutnliver.org/journal/download_pdf.php?doi=10.5009/gnl210118","host_type":"journal"},{"url":"https://www.gutnliver.org/journal/download_pdf.php?doi=10.5009/gnl210118","host_type":"publisher"},{"url":"http://pdf.medrang.co.kr/GNL/2022/016/GNL016-02-157.pdf","host_type":"publisher"},{"url":"https://doi.org/10.5009/gnl210118","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34456186","host_type":"repository"},{"url":"https://doaj.org/article/e5860c48cc0642f08021d11b504ff0ad","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8924800","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8924800","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8924800?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Inflammatory Bowel Disease","Microscopic Colitis","Eosinophilic Esophagitis","Adolescent","Crohn Disease","Disease Progression","Humans","Inflammatory Bowel Diseases","Phenotype","Recurrence"],"mesh_terms":["Adolescent","Crohn Disease","Humans","Phenotype","Recurrence","Inflammatory Bowel Diseases","Disease Progression"],"keywords":["Medicine","Disease","Clinical phenotype","Crohn's disease","Inflammatory bowel disease","Chronic disease","Intensive care medicine","Immunology","Internal medicine","Phenotype","Prognosis","Recurrence","Crohn Disease","Disease Course"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.24217560.v1","title":"Additional file 1 of Combined use of CDAI and blood indices for assessing endoscopic activity in ileocolic Crohn’s disease","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.24217560","title":"Additional file 1 of Combined use of CDAI and blood indices for assessing endoscopic activity in ileocolic Crohn’s disease","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T09:30:11.868165Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}