{"doi":"10.48550/arxiv.2302.04338","title":"Simulating the Evolution of Signaling Signatures during CART-Cell -- Tumor Cell Interactions","abstract":"Immunotherapies have been proven to have significant therapeutic efficacy in the treatment of cancer. The last decade has seen adoptive cell therapies, such as chimeric antigen receptor T-cell (CART-cell) therapy, gain FDA approval against specific cancers. Additionally, there are numerous clinical trials ongoing investigating additional designs and targets. Nevertheless, despite the excitement and promising potential of CART-cell therapy, response rates to therapy vary greatly between studies, patients, and cancers. There remains an unmet need to develop computational frameworks that more accurately predict CART-cell function and clinical efficacy. Here we present a coarse-grained model simulated with logical rules that demonstrates the evolution of signaling signatures following the inter-action between CART-cells and tumor cells and allows for in silico based prediction of CART-cell functionality prior to experimentation.","journal":"arXiv (Cornell University)","year":2023,"id":403045,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1180519,"name":"Justin Womack","orcid":"0000-0001-9957-9822","position":1,"is_corresponding":false},{"id":253486,"name":"Anthony E. Zamora","orcid":"0000-0001-5712-5339","position":2,"is_corresponding":false},{"id":426099,"name":"Scott S. Terhune","orcid":"0000-0003-3689-7094","position":3,"is_corresponding":false},{"id":426101,"name":"Ranjan K. Dash","orcid":"0000-0001-6751-0679","position":4,"is_corresponding":false},{"id":1180518,"name":"Viren Shah","orcid":"0000-0002-2570-6486","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:20:32.588152Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}