{"doi":"10.48130/animadv-0025-0029","title":"Malnutrition during gestation induces lipid metabolic disorders in maternal and fetal livers and eventually affects fetal development","abstract":null,"journal":"Animal Advances","year":2025,"id":662621,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1095272,"name":"Yun Xu","orcid":"0000-0002-6143-9282","position":1,"is_corresponding":false},{"id":1729865,"name":"Huizhen Lu","orcid":null,"position":2,"is_corresponding":false},{"id":750870,"name":"Ye Xu","orcid":"0000-0003-3309-6857","position":3,"is_corresponding":false},{"id":1729866,"name":"Caiyun Fan","orcid":null,"position":4,"is_corresponding":false},{"id":348632,"name":"Sijia Liu","orcid":"0000-0002-7433-1799","position":5,"is_corresponding":false},{"id":1729867,"name":"Zhao Zhuo","orcid":null,"position":6,"is_corresponding":false},{"id":677155,"name":"Shengyong Mao","orcid":"0000-0002-0089-9314","position":7,"is_corresponding":false},{"id":1513316,"name":"Jianbo Cheng","orcid":null,"position":8,"is_corresponding":false},{"id":659622,"name":"Wei Liu","orcid":"0000-0002-1587-9316","position":9,"is_corresponding":false},{"id":658256,"name":"Yanfeng Xue","orcid":"0000-0003-0257-3825","position":10,"is_corresponding":false},{"id":941938,"name":"Peng Jiao","orcid":"0000-0003-4039-8300","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Malnutrition during gestation induces lipid metabolic disorders in maternal and fetal livers and eventually affects fetal development","abstract":"Malnutrition is common during gestation, which threats maternal health, survival, and fetal development. The mechanisms of malnutrition-induced metabolic disorders and fetal maldevelopment are however poorly understood. In recent years, numerous studies in human and animal models have filled the gaps in the field of mother-child metabolism regarding malnutrition during gestation. This review summarizes and analyzes the lipid metabolic disorders in maternal and fetal livers, as well as fetal maldevelopment in response to malnutrition during gestation, and the regulatory mechanisms involved. Malnutrition elevates fatty acid oxidation, esterification, and lipolysis while suppressing fatty acid, cholesterol, steroid synthesis, and phospholipid metabolism both in maternal and fetal livers. Intriguingly, ketogenesis is inhibited in maternal liver but enhanced in fetal liver. Maternal malnutrition induces fetal hepatic lipid metabolic dysregulation, which suppresses DNA replication machinery and disrupts cell cycle progression, thereby creating an imbalance between cellular proliferation and apoptosis, ultimately culminating in fetal maldevelopment. Under conditions of malnutrition, non-esterified fatty acids stimulate peroxisome proliferator-activated receptor alpha (PPARA) signaling to upregulate fatty acid <italic>β</italic>-oxidation and ketogenesis, whereas <italic>β</italic>-hydroxybutyrate inhibits these metabolic processes through suppression of retinoid X receptor alpha (RXRA) signaling. Activation of PPARA/RXRA signaling pathway improves liver lipid metabolic homeostasis and alleviates oxidative stress. This review contributes to the research on mother-child nutritional metabolism and the development of novel strategies during gestation to advance the health of mother and offspring.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19162232","pmcid":null,"openalex_id":"https://openalex.org/W7108095065","authors":[],"funders":[],"total_grants":0,"fwci":2.073,"citation_percentile":0.90740129,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.maxapress.com/data/article/opr/preview/pdf/animadv-0025-0029.pdf","host_type":"journal"},{"url":"https://www.maxapress.com/data/article/opr/preview/pdf/animadv-0025-0029.pdf","host_type":"publisher"},{"url":"https://doi.org/10.48130/animadv-0025-0029","host_type":"journal"},{"url":"https://doaj.org/article/ce400961391247cb89f8e57dc3c5fc52","host_type":"repository"}],"fields_of_study":["Birth, Development, and Health","Gestational Diabetes Research and Management","Peroxisome Proliferator-Activated Receptors"],"mesh_terms":[],"keywords":["Fetus","Ketogenesis","Lipid metabolism","Fatty liver","Maldevelopment","Fatty acid","Lipolysis","Metabolic pathway"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T16:28:55.865806Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}