{"doi":"10.48035/tesis/2454/52946","title":"Asociaciones de la actividad física, la conducta sedentaria y la condición física con la salud glucémica y cardiometabólica en jóvenes con diabetes tipo 1","abstract":"The main purpose of this doctoral thesis was to determine whether the physical activity (PA), sedentary behavior and physical fitness were associated with the glycemic control and cardiovascular risk factors in children and adolescents with T1D, and if these parameters differed from those in apparently healthy peers. In order to fulfill this objective and answer a variety of questions that arose during the execution of the project, a series of reviews of existing data and analyses of our own data were carried out and reported. Thus, the Diactive-1 Cohort Study gave rise to four studies: First study: Youth with type 1 diabetes mellitus are more inactive and sedentary than apparently healthy peers: A systematic review and meta-analysis. Aim: To conduct a meta-analysis of differences in PA, sedentary behavior, and physical fitness between children and adolescents with T1D and their healthy peers. Conclusions: Keeping in mind the heterogeneity between studies in the design, population and assessment, our findings show that children and adolescents with T1D seem to be less active, more sedentary, and have lower CRF levels than their healthy peers. Second study: Is fear of hypoglycemia a major barrier to an active lifestyle in children and adolescents with type 1 diabetes? The Diactive-1 Study. Aim: To evaluate the relationship between fear of hypoglycemia (FoH) and PA and glycemic metrics in children and adolescents with T1D. Conclusions: Children and adolescents with FoH were more active, less sedentary, and had similar glycemic metrics to those without fear. Our results therefore suggest that FoH may be less of a barrier to an active lifestyle than previously believed. Third study: Association Between Physical Activity, Sedentary Behavior and Physical Fitness and Glycated Hemoglobin in Youth with Type 1 Diabetes: A Systematic Review and Meta-analysis. Aim: To meta-analyze the association between A1c and PA, sedentary behavior, and physical fitness in children and adolescents with T1D. Conclusions: Low levels of PA and CRF and extensive sedentary behavior may explain part of the variance in A1c and part of the risk for poor glycemic control in youth with T1D. Fourth study: Handgrip strength, cardiometabolic risk, and body composition in youth with type 1 diabetes. Aim: To explore the association between handgrip strength, cardiometabolic risk, and body composition in youth with T1D. Conclusions: Healthy handgrip strength provides significant cardiometabolic and body composition benefits for youth with T1D. This tool could be considered of potential clinical value in incorporating assessments like handgrip tests to monitor and intervene regarding cardiometabolic health.","journal":"Academica-e (Universidad Pública de Navarra)","year":2025,"id":560470,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1462403,"name":"Nidia Huerta‐Uribe","orcid":"0000-0001-5443-5788","position":0,"is_corresponding":true}],"reference_count":243,"raw_metadata":null,"created_at":"2026-07-19T02:55:42.883572Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}