{"doi":"10.47895/amp.vi0.2350","title":"A Genetic Polymorphism in GCKR may be Associated with Low High-Density Lipoprotein Cholesterol Phenotype among Filipinos: A Case-Control Study","abstract":"Background. Low levels of high-density lipoprotein cholesterol (HDL-c) is a well-recognized risk factor in the development of cardiovascular diseases. Associated gene variants for low HDL-c have already been demonstrated in various populations. Such associations have yet to be established among Filipinos who reportedly have a much higher prevalence of low HDL-c levels compared to other races. Objective. To determine the association of selected genetic variants and clinical factors with low HDL-c phenotype in Filipinos. Methods. An age- and sex-matched case-control study was conducted among adult Filipino participants with serum HDL-c concentration less than 35 mg/dL (n=61) and those with HDL-c levels of more than 40 mg/dL (n=116). Genotyping was done using DNA obtained from blood samples. Candidate variants were correlated with the low HDL-c phenotype using chi-squared test and conditional logistic regression analysis. Results. Twelve single nucleotide polymorphisms (SNPs) were associated with low HDL-c phenotype among Filipinos with univariate regression analysis. The variant rs1260326 of glucokinase regulator (GCKR) (CT genotype: adjusted OR=5.17; p-value=0.007; TT genotype: adjusted OR=6.28; p-value=0.027) remained associated with low HDL-c phenotype, together with hypertension and elevated body mass index, after multiple regression analysis. Conclusion. The variant rs1260326 near GCKR is associated with low HDL-c phenotype among Filipinos. Its role in the expression of low HDL-c phenotype should be further investigated prior to the development of possible clinical applications.","journal":"Acta Medica Philippina","year":2021,"id":212012,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":613800,"name":"Jose B. Nevado","orcid":"0000-0002-5730-7105","position":1,"is_corresponding":false},{"id":802405,"name":"Eddieson M. Gonzales","orcid":null,"position":2,"is_corresponding":false},{"id":802406,"name":"Adrian John P. Bejarin","orcid":null,"position":3,"is_corresponding":false},{"id":801986,"name":"Aimee Yvonne Criselle L. Aman","orcid":"0000-0002-6528-1451","position":4,"is_corresponding":false},{"id":801987,"name":"Elmer Jasper B. Llanes","orcid":"0000-0003-3127-7056","position":5,"is_corresponding":false},{"id":802407,"name":"Jose Donato A. Magno","orcid":null,"position":6,"is_corresponding":false},{"id":801988,"name":"Deborah Ignacia D. Ona","orcid":"0000-0002-7150-1051","position":7,"is_corresponding":false},{"id":801989,"name":"Felix Eduardo R. Punzalan","orcid":"0000-0003-3315-3161","position":8,"is_corresponding":false},{"id":802408,"name":"Paul Ferdinand M. Reganit","orcid":null,"position":9,"is_corresponding":false},{"id":802409,"name":"Lourdes Ella G. Santos","orcid":null,"position":10,"is_corresponding":false},{"id":802410,"name":"Richard Henry Tiongco","orcid":null,"position":11,"is_corresponding":false},{"id":802411,"name":"Jaime Alfonso M. Aherrera","orcid":null,"position":12,"is_corresponding":false},{"id":801990,"name":"Lauro L. Abrahan","orcid":"0000-0002-4783-8105","position":13,"is_corresponding":false},{"id":802412,"name":"Charlene F. Agustin","orcid":null,"position":14,"is_corresponding":false},{"id":802413,"name":"Eva Maria C. Cutiongco – de la Paz","orcid":null,"position":15,"is_corresponding":false},{"id":39218,"name":"Rody G. Sy","orcid":"0000-0002-9637-3973","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-18T23:52:23.670339Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}