{"doi":"10.46439/signaling.3.055","title":"The role of stress granules in heavy metal-induced carcinogenesis","abstract":"In our recent published study entitled “Stress granules play a critical role in hexavalent chromium-induced malignancy in a G3BP1-dependent manner”, we explored how hexavalent chromium [Cr(VI)] exposure induces stress granule (SG) formation in human bronchial epithelial cells and how SGs contribute to the malignancy. We found that the loss of the SG core protein Ras-GAP SH3 domain-binding protein 1 (G3BP1) reduced SG formation and malignant properties. The results support that SGs play a critical role in mediating Cr(VI)-induced malignancy in a G3BP1-dependent manner, representing a novel mechanism and a potential therapeutic target. In this commentary, we introduce more in-depth background, summarize key findings of the published work, present additional data addressing a related question, and discuss emerging questions and future research directions.","journal":"Cell Signaling","year":2025,"id":540334,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":432866,"name":"Megan Carver","orcid":"0000-0003-3637-5253","position":1,"is_corresponding":false},{"id":351084,"name":"Haining Zhu","orcid":"0000-0001-5498-6694","position":2,"is_corresponding":false},{"id":1274109,"name":"Lei Wang","orcid":"0000-0001-8510-966X","position":3,"is_corresponding":false},{"id":1428460,"name":"Rukayat Aromokeye","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:52:38.861025Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}